Introduction
Appendicitis, the inflammation of the vermiform appendix, is a common cause of acute abdominal pain requiring surgical intervention. This small, finger-shaped organ attached to the cecum in the large intestine, typically in the right lower quadrant (RLQ), can be located elsewhere depending on individual anatomical variations or conditions like pregnancy or prior surgeries. Its narrow lumen makes it susceptible to obstruction, often by fecaliths, leading to inflammation and potential infection. Appendicitis is a prevalent surgical emergency, particularly affecting individuals between 5 and 45 years old, with a slightly higher incidence in males. While usually acute, it can sometimes present chronically, especially if perforation and abscess formation are contained, resulting in a slower symptom onset. The appendix’s function is still debated, but current understanding points to its role in immunoprotection and as a lymphoid organ, particularly in younger individuals, and potentially as a reservoir for beneficial gut bacteria.
5 Essential Nursing Diagnoses for Appendicitis
Nurses play a crucial role in the care of patients with appendicitis, from initial assessment to post-operative management and discharge education. Formulating accurate nursing diagnoses is fundamental for creating effective care plans. Here are 5 key nursing diagnoses relevant to appendicitis:
- Acute pain related to inflammation and obstruction of the appendix.
- Risk for fluid volume deficit related to nausea, vomiting, decreased appetite, and reduced oral intake.
- Risk for infection related to potential appendiceal rupture, perforation, and surgical incision.
- Risk for deep vein thrombosis (DVT) related to decreased mobility post-surgery and hospitalization.
- Anxiety related to hospitalization, pain, uncertain diagnosis, and surgical intervention.
We will delve deeper into each of these nursing diagnoses throughout this guide, providing a comprehensive understanding of appendicitis and the essential nursing care required.
Understanding Appendicitis: Causes, Risk Factors, and Assessment
Causes
Appendicitis is primarily caused by an obstruction of the appendiceal lumen, which can lead to a cascade of events including inflammation, ischemia, perforation, and abscess formation or peritonitis. This obstruction can be due to:
- Fecaliths: Hardened fecal masses are the most common cause in adults.
- Lymphoid hyperplasia: Enlargement of lymphoid tissue, often due to infection, is more common in children and young adults.
- Infections: Parasitic infections can also cause obstruction.
- Tumors: Benign or malignant tumors, though less common, can obstruct the appendix.
Obstruction increases intraluminal pressure, leading to small vessel occlusion and lymphatic stasis. The appendix then fills with mucus, distends, and becomes ischemic. Bacterial overgrowth follows, with Escherichia coli, Peptostreptococcus, Bacteroides, and Pseudomonas being common culprits. If inflammation and necrosis progress, the appendix may perforate, resulting in localized abscess or generalized peritonitis.
Risk Factors
Appendicitis is a common condition, but certain factors increase the risk:
- Age: Most common between 5 and 45 years old, but can occur at any age.
- Gender: Slightly higher risk in males.
- Family history: A family history of appendicitis may slightly increase risk.
- Cystic fibrosis: Individuals with cystic fibrosis have a higher risk.
Assessment
Classic appendicitis presentation begins with generalized or periumbilical abdominal pain that shifts to the right lower quadrant (RLQ). As inflammation intensifies and irritates the parietal peritoneum, pain becomes localized in the RLQ. Symptoms may include:
- Abdominal pain: Initially periumbilical, migrating to RLQ, worsening with movement, coughing.
- Anorexia: Loss of appetite is common.
- Nausea and Vomiting: Often follow the onset of pain.
- Fever: Present in about 40% of patients.
- Altered Bowel Habits: Diarrhea or constipation can occur.
- Malaise: General feeling of discomfort or illness.
- Urinary Symptoms: Frequency or urgency may occur if the appendix is near the bladder.
Physical examination findings can be subtle, especially early on. Signs of peritoneal inflammation develop as the condition progresses:
- RLQ tenderness: Direct tenderness to palpation in the right lower quadrant.
- Guarding: Involuntary muscle contraction to protect the inflamed area.
- Rebound tenderness: Pain worse upon release of pressure than application.
- Rovsing’s sign: RLQ pain upon palpation of the left lower quadrant.
- Psoas sign: Pain with right hip extension, indicating retrocecal appendix irritation of the psoas muscle.
- Obturator sign: Pain with internal rotation of the flexed right hip, suggesting pelvic appendix irritation of the obturator internus muscle.
- Increased pain with cough or movement: Sign of peritoneal irritation.
- Rigid abdomen: “Board-like” abdomen in severe cases, indicating peritonitis.
Symptoms typically progress from early appendicitis within 12-24 hours to perforation after 48 hours. Most patients seek medical attention within 24 hours of symptom onset. The risk of rupture is approximately 2% at 36 hours and increases by about 5% every 12 hours thereafter.
Image: Abdomen CT scan showing acute appendicitis with periappendiceal inflammation. The alt text emphasizes the diagnostic imaging modality and the condition visualized, enhancing SEO for searches related to appendicitis imaging.
Diagnosis and Medical Management of Appendicitis
Evaluation
Diagnosis of appendicitis often involves a combination of clinical assessment and diagnostic testing:
- Laboratory Tests:
- Complete Blood Count (CBC): Elevated white blood cell (WBC) count is common but not always present (normal in about one-third of cases).
- Imaging Studies:
- CT scan of abdomen and pelvis: Highly accurate and frequently used in adults.
- Ultrasound: Often used in children and pregnant women to minimize radiation exposure.
- MRI: An alternative, especially in pregnant women.
Appendicitis diagnosis is often primarily clinical, based on patient history and physical exam findings. Scoring systems like the Alvarado score can aid in risk stratification.
Medical Management
The primary treatment for acute appendicitis is appendectomy, surgical removal of the appendix.
- Appendectomy:
- Laparoscopic appendectomy: Preferred approach due to less pain, quicker recovery, and smaller incisions, allowing for broader abdominal exploration.
- Open appendectomy: May be necessary in cases of abscess or complicated infection.
- Non-operative Management: In select cases of uncomplicated appendicitis, antibiotic therapy alone is being explored as an alternative to surgery. However, appendectomy remains the gold standard.
- Preoperative Antibiotics: Broad-spectrum antibiotics are typically administered. The necessity for routine preoperative antibiotics in uncomplicated cases is debated among surgeons.
- Percutaneous Drainage: For patients with perforated appendicitis and abscess, percutaneous drainage by interventional radiology may be performed to stabilize the patient and allow for delayed appendectomy.
Image: Ultrasound image of the right lower quadrant showing acute appendicitis. The alt text is optimized to include “ultrasound,” “acute appendicitis,” and “RLQ,” targeting search terms related to appendicitis diagnosis using ultrasound.
Comprehensive Nursing Management for Appendicitis Patients
Nursing care is crucial throughout the appendicitis patient’s journey. Key nursing interventions are centered around the 5 nursing diagnoses identified earlier:
1. Acute Pain Management
- Assessment: Regularly assess pain using a pain scale (e.g., 0-10 numeric scale, FACES). Note pain location, quality, and aggravating/relieving factors.
- Pharmacological Interventions: Administer prescribed analgesics, typically opioids and/or non-opioids, as ordered. Ensure timely and effective pain relief.
- Non-pharmacological Interventions:
- Positioning: Encourage comfortable positioning, often in a semi-Fowler’s position with knees flexed to reduce abdominal tension.
- Relaxation techniques: Deep breathing exercises, distraction, and guided imagery can complement pain medication.
- DO NOT APPLY HEAT: Avoid applying heat to the abdomen as it can increase blood flow and potentially lead to rupture. Cold packs may be used cautiously, if ordered, but are generally less effective for acute abdominal pain.
2. Fluid Volume Deficit Prevention
- Assessment: Monitor for signs of dehydration:
- Vital signs: Tachycardia, hypotension.
- Fluid balance: Intake and output, urine specific gravity.
- Mucous membranes: Dryness.
- Skin turgor: Decreased elasticity.
- Interventions:
- Oral fluids: Encourage oral fluid intake if tolerated and not contraindicated (NPO status pre-surgery).
- Intravenous fluids: Administer IV fluids as prescribed to correct and prevent dehydration, especially if the patient is NPO or experiencing vomiting.
- Antiemetics: Administer antiemetics as prescribed to manage nausea and vomiting.
3. Infection Risk Reduction
- Pre-operative care:
- Antibiotic administration: Administer prescribed preoperative antibiotics as ordered.
- Skin preparation: Prepare surgical site as per protocol.
- Post-operative care:
- Wound care: Maintain a clean and dry surgical incision site. Change dressings as needed, following sterile technique.
- Incision assessment: Frequently assess incision for signs of infection (redness, warmth, swelling, drainage, pain).
- Vital signs monitoring: Monitor temperature and heart rate for signs of infection.
- Antibiotic administration: Continue prescribed postoperative antibiotics.
4. Deep Vein Thrombosis (DVT) Risk Mitigation
- Assessment: Assess risk factors for DVT: immobility, surgery, age, obesity, history of DVT.
- Interventions:
- Early ambulation: Encourage early ambulation as soon as medically stable post-surgery.
- Leg exercises: Encourage in-bed leg exercises (ankle pumps, calf raises) if ambulation is limited.
- Mechanical prophylaxis: Apply sequential compression devices (SCDs) and/or anti-embolism stockings (TED hose) as ordered, especially for immobile patients.
- Anticoagulation: Administer prophylactic anticoagulants (e.g., heparin, enoxaparin) as prescribed for high-risk patients.
5. Anxiety Management
- Assessment: Assess patient’s anxiety level and coping mechanisms.
- Interventions:
- Therapeutic communication: Provide clear, honest information about diagnosis, treatment plan, and expected recovery. Answer questions and address concerns.
- Emotional support: Offer reassurance and emotional support.
- Education: Educate patient and family about appendicitis, surgical procedure, and post-operative care.
- Create a calm environment: Minimize environmental stressors.
- Involve family: Include family in education and support, as appropriate.
When to Seek Immediate Medical Attention
Educate patients and caregivers about warning signs that require immediate medical attention:
- Signs of Peritonitis:
- Severe, worsening abdominal pain: Especially if the abdomen becomes rigid or “board-like.”
- Decreased movement: Patient may be very still, avoiding movement to minimize pain.
- Shallow breathing: Due to pain with deep breaths.
- Signs of Sepsis/Infection:
- Fever and chills.
- Increased heart rate (tachycardia).
- Change in mental status.
- Post-operative Wound Infection Signs:
- Increased redness, tenderness, swelling at incision site.
- Drainage from incision.
- Increasing pain at incision site.
Promptly reporting these symptoms to the healthcare provider is crucial for timely intervention and preventing complications.
Expected Outcomes and Monitoring
Outcome Identification
Expected outcomes for patients with appendicitis and related nursing diagnoses include:
- Pain relief: Patient reports decreased or relieved pain.
- Fluid balance: Patient maintains adequate hydration, with balanced intake and output.
- Infection prevention/management: Patient remains free from infection or infection is effectively treated. Surgical incision remains intact without signs of infection.
- DVT prevention: Patient does not develop DVT.
- Anxiety reduction: Patient’s anxiety is reduced, and they express understanding of their condition and treatment plan.
- Adequate elimination: Patient maintains normal bowel function post-operatively or constipation is prevented/managed.
Monitoring
Continuous monitoring is essential to assess patient progress and detect any complications:
- Vital Signs: Regularly monitor temperature, heart rate, blood pressure, and respiratory rate to detect changes indicating infection, dehydration, or other complications.
- Pain Level and Location: Continuously assess pain characteristics to evaluate pain management effectiveness and identify any changes that may indicate worsening condition or complications.
- Eating and Bowel Habits: Monitor appetite, nausea, vomiting, and bowel movements to assess gastrointestinal function and identify potential issues like ileus or constipation.
- Laboratory Values: Monitor WBC count and other relevant labs to assess for infection and inflammatory response. Be aware that appendicitis can occur even with normal lab values.
- Surgical Incision Site: Regularly monitor the surgical incision for signs of infection, proper healing, and drainage.
Image: CT scan showing appendicitis with a surrounding abscess. The alt text effectively uses keywords like “CT scan,” “appendicitis,” and “abscess” to improve searchability for related medical imaging and diagnosis topics.
Patient Education and Health Promotion
Patient education is vital for recovery and preventing complications after discharge:
- Incision Care: Provide detailed instructions on incision care, including cleaning, dressing changes, and signs of infection to watch for.
- Follow-up Appointments: Ensure patient understands the importance of scheduled follow-up appointments with the surgeon or primary care provider for wound check and suture/staple removal (typically 5-7 days post-op).
- Activity Restrictions: Advise patient to gradually resume normal activities within a few days to a week, but to avoid strenuous activity and heavy lifting for 4-6 weeks, or as advised by their provider. Encourage frequent, short walks.
- Medication Education:
- Antibiotics: If prescribed, emphasize the importance of completing the full course of antibiotics, even if feeling better, and taking them with food to minimize stomach upset.
- Pain medication: If opioids are prescribed, educate about potential side effects like constipation and advise use of stool softeners. Warn against driving or operating heavy machinery while taking opioids.
- Warning Signs: Reinforce the warning signs discussed earlier (peritonitis, infection, wound infection) and instruct patient to promptly contact their clinician if they experience any of these.
Risk Management and Documentation
Accurate and timely documentation is crucial in the care of appendicitis patients. Key documentation points include:
- Pain Assessment: Document patient’s pain description, intensity (using pain scale), location, and response to pain management interventions.
- Laboratory Results: Document all lab results and note if abnormal results were communicated to the provider and the provider’s response.
- Surgical Site Assessment: Document surgical site appearance, wound care provided, dressing changes, and any drainage (including type and amount).
- Signs and Symptoms of Infection: Document any signs or symptoms of infection and actions taken.
- Patient Education: Document all patient education provided, including topics covered and patient understanding.
- Plan of Care: Document the nursing plan of care and any modifications.
- Provider Communication: Document all communication with the provider, including time, reason for contact, provider response, and orders received.
Discharge Planning
Discharge planning begins upon admission to ensure a smooth transition home. Key elements include:
- Review of Discharge Instructions: Reinforce all patient education points discussed earlier (incision care, follow-up, activity restrictions, medications, warning signs).
- Medication Reconciliation: Ensure patient has prescriptions for all necessary medications and understands how to take them.
- Follow-up Appointment Scheduling: Confirm follow-up appointment is scheduled and patient has appointment details.
- Home Health or Resources: Arrange for home health services or connect patient with community resources if needed.
- Written Discharge Instructions: Provide written discharge instructions that are clear, concise, and easy to understand.
Key Considerations and Potential Complications
Special Populations
- Perforated Appendicitis with Abscess: Patients with perforated appendicitis and abscess without peritonitis may be initially managed with percutaneous drainage and antibiotics, followed by interval appendectomy 6-10 weeks later.
- Elderly Patients: Appendicitis in the elderly may present atypically and have higher morbidity and mortality rates.
Potential Complications
Complications of appendicitis and appendectomy can include:
- Surgical site infections.
- Intra-abdominal abscess.
- Prolonged ileus.
- Enterocutaneous fistula.
- Small bowel obstruction.
- Stump appendicitis: Rare condition where inflammation occurs in the remaining appendiceal stump after incomplete appendectomy.
Differential Diagnosis
It’s important to consider other conditions that can mimic appendicitis, such as:
- Crohn’s disease: Especially ileocecal Crohn’s disease. If Crohn’s is suspected during surgery, and the base of the appendix is involved, the appendix should be left in place to avoid complications. If the base is spared, appendectomy can proceed to prevent future diagnostic confusion.
Conclusion
Appendicitis remains a significant cause of abdominal pain requiring prompt diagnosis and treatment. Nurses are vital in providing comprehensive care, from initial assessment and pre-operative preparation to post-operative management and patient education. By understanding the key nursing diagnoses – acute pain, risk for fluid volume deficit, risk for infection, risk for DVT, and anxiety – nurses can develop and implement effective care plans to optimize patient outcomes and promote recovery. Continuous monitoring, patient education, and meticulous documentation are essential components of high-quality nursing care for patients with appendicitis.
References
- Vaos G, Dimopoulou A, Gkioka E, Zavras N. Immediate surgery or conservative treatment for complicated acute appendicitis in children? A meta-analysis. J Pediatr Surg. 2019 Jul;54(7):1365-1371. [PubMed: 30115448]
- Gignoux B, Blanchet MC, Lanz T, Vulliez A, Saffarini M, Bothorel H, Robert M, Frering V. Should ambulatory appendectomy become the standard treatment for acute appendicitis? World J Emerg Surg. 2018;13:28. [PMC free article: PMC6025707] [PubMed: 29988464]
- Eng KA, Abadeh A, Ligocki C, Lee YK, Moineddin R, Adams-Webber T, Schuh S, Doria AS. Acute Appendicitis: A Meta-Analysis of the Diagnostic Accuracy of US, CT, and MRI as Second-Line Imaging Tests after an Initial US. Radiology. 2018 Sep;288(3):717-727. [PubMed: 29916776]
- Kartal İ. Childhood neuroendocrine tumors of the digestive system: A single center experience. Medicine (Baltimore). 2022 Feb 11;101(6):e28795. [PMC free article: PMC8830841] [PubMed: 35147110]
- Khan MS, Chaudhry MBH, Shahzad N, Tariq M, Memon WA, Alvi AR. Risk of appendicitis in patients with incidentally discovered appendicoliths. J Surg Res. 2018 Jan;221:84-87. [PubMed: 29229158]
- Stringer MD. Acute appendicitis. J Paediatr Child Health. 2017 Nov;53(11):1071-1076. [PubMed: 29044790]
- Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015 Sep 26;386(10000):1278-1287. [PubMed: 26460662]
- Ucar Karabulut K, Erinanc H, Yonar A, Kisinma A, Ucar Y. Correlation of histological diagnosis and laboratory findings in distinguishing acute appendicitis and lymphoid hyperplasia. Ann Surg Treat Res. 2022 Nov;103(5):306-311. [PMC free article: PMC9678668] [PubMed: 36452309]
- Narula N, Gibbs KE, Kong F, Mukherjee I. Appendiceal Intussusception, Diverticula, and Fecalith Associated With Appendicitis. Am Surg. 2023 Dec;89(12):6257-6259. [PubMed: 36074037]
- Buckius MT, McGrath B, Monk J, Grim R, Bell T, Ahuja V. Changing epidemiology of acute appendicitis in the United States: study period 1993-2008. J Surg Res. 2012 Jun 15;175(2):185-90. [PubMed: 22099604]
- Sahm M, Koch A, Schmidt U, Wolff S, Pross M, Gastinger I, Lippert H. [Acute appendicitis – clinical health-service research on the current surgical therapy]. Zentralbl Chir. 2013 Jun;138(3):270-7. [PubMed: 22426968]
- Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990 Nov;132(5):910-25. [PubMed: 2239906]
- Téoule P, Laffolie J, Rolle U, Reissfelder C. Acute Appendicitis in Childhood and Adulthood. Dtsch Arztebl Int. 2020 Nov 06;117(45):764-774. [PMC free article: PMC7898047] [PubMed: 33533331]
- Hamilton AL, Kamm MA, Ng SC, Morrison M. Proteus spp. as Putative Gastrointestinal Pathogens. Clin Microbiol Rev. 2018 Jul;31(3) [PMC free article: PMC6056842] [PubMed: 29899011]
- Redden M, Ghadiri M. Acute appendicitis with associated trichobezoar of feline hair. J Surg Case Rep. 2022 Mar;2022(3):rjac133. [PMC free article: PMC8963297] [PubMed: 35355580]
- Correa J, Jimeno J, Vallverdu H, Bizzoca C, Collado-Roura F, Estalella L, Hermoso J, Silva N, Sanchez-Pradell C, Parés D. Correlation between intraoperative surgical diagnosis of complicated acute appendicitis and the pathology report: clinical implications. Surg Infect (Larchmt). 2015 Feb;16(1):41-4. [PubMed: 25761079]
- Hoffmann JC, Trimborn CP, Hoffmann M, Schröder R, Förster S, Dirks K, Tannapfel A, Anthuber M, Hollerweger A. Classification of acute appendicitis (CAA): treatment directed new classification based on imaging (ultrasound, computed tomography) and pathology. Int J Colorectal Dis. 2021 Nov;36(11):2347-2360. [PubMed: 34143276]
- Snyder MJ, Guthrie M, Cagle S. Acute Appendicitis: Efficient Diagnosis and Management. Am Fam Physician. 2018 Jul 01;98(1):25-33. [PubMed: 30215950]
- van Aerts RMM, van de Laarschot LFM, Banales JM, Drenth JPH. Clinical management of polycystic liver disease. J Hepatol. 2018 Apr;68(4):827-837. [PubMed: 29175241]
- Iwamoto Y, Onishi T, Suzuki R, Arima K, Sugimura Y. Uretero-appendiceal fistula. Int J Urol. 2008 Feb;15(2):180-1. [PubMed: 18269461]
- Yang HR, Wang YC, Chung PK, Chen WK, Jeng LB, Chen RJ. Laboratory tests in patients with acute appendicitis. ANZ J Surg. 2006 Jan-Feb;76(1-2):71-4. [PubMed: 16483301]
- Withers AS, Grieve A, Loveland JA. Correlation of white cell count and CRP in acute appendicitis in paediatric patients. S Afr J Surg. 2019 Dec;57(4):40. [PubMed: 31773931]
- Rao PM. Cecal apical changes with appendicitis: diagnosing appendicitis when the appendix is borderline abnormal or not seen. J Comput Assist Tomogr. 1999 Jan-Feb;23(1):55-9. [PubMed: 10050808]
- Pooler BD, Repplinger MD, Reeder SB, Pickhardt PJ. MRI of the Nontraumatic Acute Abdomen: Description of Findings and Multimodality Correlation. Gastroenterol Clin North Am. 2018 Sep;47(3):667-690. [PubMed: 30115443]
- Swenson DW, Ayyala RS, Sams C, Lee EY. Practical Imaging Strategies for Acute Appendicitis in Children. AJR Am J Roentgenol. 2018 Oct;211(4):901-909. [PubMed: 30106612]
- Kim DW, Suh CH, Yoon HM, Kim JR, Jung AY, Lee JS, Cho YA. Visibility of Normal Appendix on CT, MRI, and Sonography: A Systematic Review and Meta-Analysis. AJR Am J Roentgenol. 2018 Sep;211(3):W140-W150. [PubMed: 30040469]
- Hwang ME. Sonography and Computed Tomography in Diagnosing Acute Appendicitis. Radiol Technol. 2018 Jan;89(3):224-237. [PubMed: 29298941]
- Kave M, Parooie F, Salarzaei M. Pregnancy and appendicitis: a systematic review and meta-analysis on the clinical use of MRI in diagnosis of appendicitis in pregnant women. World J Emerg Surg. 2019;14:37. [PMC free article: PMC6647167] [PubMed: 31367227]
- Awayshih MMA, Nofal MN, Yousef AJ. Evaluation of Alvarado score in diagnosing acute appendicitis. Pan Afr Med J. 2019;34:15. [PMC free article: PMC6859007] [PubMed: 31762884]
- CODA Collaborative. Flum DR, Davidson GH, Monsell SE, Shapiro NI, Odom SR, Sanchez SE, Drake FT, Fischkoff K, Johnson J, Patton JH, Evans H, Cuschieri J, Sabbatini AK, Faine BA, Skeete DA, Liang MK, Sohn V, McGrane K, Kutcher ME, Chung B, Carter DW, Ayoung-Chee P, Chiang W, Rushing A, Steinberg S, Foster CS, Schaetzel SM, Price TP, Mandell KA, Ferrigno L, Salzberg M, DeUgarte DA, Kaji AH, Moran GJ, Saltzman D, Alam HB, Park PK, Kao LS, Thompson CM, Self WH, Yu JT, Wiebusch A, Winchell RJ, Clark S, Krishnadasan A, Fannon E, Lavallee DC, Comstock BA, Bizzell B, Heagerty PJ, Kessler LG, Talan DA. A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis. N Engl J Med. 2020 Nov 12;383(20):1907-1919. [PubMed: 33017106]
- Hansson J, Körner U, Khorram-Manesh A, Solberg A, Lundholm K. Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients. Br J Surg. 2009 May;96(5):473-81. [PubMed: 19358184]
- Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, Rex L, Badume I, Granström L. Appendectomy versus antibiotic treatment in acute appendicitis. a prospective multicenter randomized controlled trial. World J Surg. 2006 Jun;30(6):1033-7. [PubMed: 16736333]
- Salminen P, Tuominen R, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Hurme S, Mecklin JP, Sand J, Virtanen J, Jartti A, Grönroos JM. Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA. 2018 Sep 25;320(12):1259-1265. [PMC free article: PMC6233612] [PubMed: 30264120]
- Vons C, Barry C, Maitre S, Pautrat K, Leconte M, Costaglioli B, Karoui M, Alves A, Dousset B, Valleur P, Falissard B, Franco D. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011 May 07;377(9777):1573-9. [PubMed: 21550483]
- Writing Group for the CODA Collaborative. Zhang IY, Voldal EC, Davidson GH, Liao JM, Thompson CM, Self WH, Kao LS, Cherry-Bukowiec J, Raghavendran K, Kaji AH, DeUgarte DA, Gonzalez E, Mandell KA, Ohe K, Siparsky N, Price TP, Evans DC, Victory J, Chiang W, Jones A, Kutcher ME, Ciomperlik H, Liang MK, Evans HL, Faine BA, Neufeld M, Sanchez SE, Krishnadasan A, Comstock BA, Heagerty PJ, Lawrence SO, Monsell SE, Fannon EEC, Kessler LG, Talan DA, Flum DR. Association of Patient Belief About Success of Antibiotics for Appendicitis and Outcomes: A Secondary Analysis of the CODA Randomized Clinical Trial. JAMA Surg. 2022 Dec 01;157(12):1080-1087. [PMC free article: PMC9535504] [PubMed: 36197656]
- Sartelli M, Baiocchi GL, Di Saverio S, Ferrara F, Labricciosa FM, Ansaloni L, Coccolini F, Vijayan D, Abbas A, Abongwa HK, Agboola J, Ahmed A, Akhmeteli L, Akkapulu N, Akkucuk S, Altintoprak F, Andreiev AL, Anyfantakis D, Atanasov B, Bala M, Balalis D, Baraket O, Bellanova G, Beltran M, Melo RB, Bini R, Bouliaris K, Brunelli D, Castillo A, Catani M, Che Jusoh A, Chichom-Mefire A, Cocorullo G, Coimbra R, Colak E, Costa S, Das K, Delibegovic S, Demetrashvili Z, Di Carlo I, Kiseleva N, El Zalabany T, Faro M, Ferreira M, Fraga GP, Gachabayov M, Ghnnam WM, Giménez Maurel T, Gkiokas G, Gomes CA, Griffiths E, Guner A, Gupta S, Hecker A, Hirano ES, Hodonou A, Hutan M, Ioannidis O, Isik A, Ivakhov G, Jain S, Jokubauskas M, Karamarkovic A, Kauhanen S, Kaushik R, Kavalakat A, Kenig J, Khokha V, Khor D, Kim D, Kim JI, Kong V, Lasithiotakis K, Leão P, Leon M, Litvin A, Lohsiriwat V, López-Tomassetti Fernandez E, Lostoridis E, Maciel J, Major P, Dimova A, Manatakis D, Marinis A, Martinez-Perez A, Marwah S, McFarlane M, Mesina C, Pędziwiatr M, Michalopoulos N, Misiakos E, Mohamedahmed A, Moldovanu R, Montori G, Mysore Narayana R, Negoi I, Nikolopoulos I, Novelli G, Novikovs V, Olaoye I, Omari A, Ordoñez CA, Ouadii M, Ozkan Z, Pal A, Palini GM, Partecke LI, Pata F, Pędziwiatr M, Pereira Júnior GA, Pintar T, Pisarska M, Ploneda-Valencia CF, Pouggouras K, Prabhu V, Ramakrishnapillai P, Regimbeau JM, Reitz M, Rios-Cruz D, Saar S, Sakakushev B, Seretis C, Sazhin A, Shelat V, Skrovina M, Smirnov D, Spyropoulos C, Strzałka M, Talving P, Teixeira Gonsaga RA, Theobald G, Tomadze G, Torba M, Tranà C, Ulrych J, Uzunoğlu MY, Vasilescu A, Occhionorelli S, Venara A, Vereczkei A, Vettoretto N, Vlad N, Walędziak M, Yilmaz TU, Yuan KC, Yunfeng C, Zilinskas J, Grelpois G, Catena F. Prospective Observational Study on acute Appendicitis Worldwide (POSAW). World J Emerg Surg. 2018;13:19. [PMC free article: PMC5902943] [PubMed: 29686725]
- Harnoss JC, Zelienka I, Probst P, Grummich K, Müller-Lantzsch C, Harnoss JM, Ulrich A, Büchler MW, Diener MK. Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Systematic Review and Meta-analysis of Controlled Trials (PROSPERO 2015: CRD42015016882). Ann Surg. 2017 May;265(5):889-900. [PubMed: 27759621]
- Kumar S, Jalan A, Patowary BN, Shrestha S. Laparoscopic Appendectomy Versus Open Appendectomy for Acute Appendicitis: A Prospective Comparative Study. 2016 Jul-Sept.Kathmandu Univ Med J (KUMJ). 14(55):244-248. [PubMed: 28814687]
- Zani A, Hall NJ, Rahman A, Morini F, Pini Prato A, Friedmacher F, Koivusalo A, van Heurn E, Pierro A. European Paediatric Surgeons’ Association Survey on the Management of Pediatric Appendicitis. Eur J Pediatr Surg. 2019 Feb;29(1):53-61. [PubMed: 30112745]
- Antonacci N, Ricci C, Taffurelli G, Monari F, Del Governatore M, Caira A, Leone A, Cervellera M, Minni F, Cola B. Laparoscopic appendectomy: Which factors are predictors of conversion? A high-volume prospective cohort study. Int J Surg. 2015 Sep;21:103-7. [PubMed: 26231996]
- Thambidorai CR, Aman Fuad Y. Laparoscopic appendicectomy for complicated appendicitis in children. Singapore Med J. 2008 Dec;49(12):994-7. [PubMed: 19122949]
- Siribumrungwong B, Chantip A, Noorit P, Wilasrusmee C, Ungpinitpong W, Chotiya P, Leerapan B, Woratanarat P, McEvoy M, Attia J, Thakkinstian A. Comparison of Superficial Surgical Site Infection Between Delayed Primary Versus Primary Wound Closure in Complicated Appendicitis: A Randomized Controlled Trial. Ann Surg. 2018 Apr;267(4):631-637. [PMC free article: PMC5865487] [PubMed: 28796014]
- Turk E, Acimis NM, Karaca F, Edirne Y, Tan A, Kilic C. The effect on postoperative pain of pulling the rectus muscle medially during open appendectomy surgery. Minerva Chir. 2014 Jun;69(3):141-6. [PubMed: 24970302]
- Hucl T, Benes M, Kocik M, Splichalova A, Maluskova J, Krak M, Lanska V, Heczkova M, Kieslichova E, Oliverius M, Spicak J. Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES. Gastroenterol Res Pract. 2016;2016:7320275. [PMC free article: PMC4923531] [PubMed: 27403157]
- Khashab MA, Kalloo AN. NOTES: current status and new horizons. Gastroenterology. 2012 Apr;142(4):704-710.e1. [PubMed: 22349111]
- Ahmed K, Wang TT, Patel VM, Nagpal K, Clark J, Ali M, Deeba S, Ashrafian H, Darzi A, Athanasiou T, Paraskeva P. The role of single-incision laparoscopic surgery in abdominal and pelvic surgery: a systematic review. Surg Endosc. 2011 Feb;25(2):378-96. [PubMed: 20623239]
- Jiang J, Wu Y, Tang Y, Shen Z, Chen G, Huang Y, Zheng S, Zheng Y, Dong R. A novel nomogram for the differential diagnosis between advanced and early appendicitis in pediatric patients. Biomark Med. 2019 Oct;13(14):1157-1173. [PubMed: 31559834]
- Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E. Appendiceal cancer : a review of the literature. Acta Gastroenterol Belg. 2020 Jul-Sep;83(3):441-448. [PubMed: 33094592]
- Zhang K, Meyerson C, Kassardjian A, Westbrook LM, Zheng W, Wang HL. Goblet Cell Carcinoid/Carcinoma: An Update. Adv Anat Pathol. 2019 Mar;26(2):75-83. [PubMed: 30601149]
- Marte A, Sabatino MD, Cautiero P, Accardo M, Romano M, Parmeggiani P. Unexpected finding of laparoscopic appendectomy: appendix MALT lymphoma in children. Pediatr Surg Int. 2008 Apr;24(4):471-3. [PubMed: 17628810]
- Xie X, Zhou Z, Song Y, Li W, Diao D, Dang C, Zhang H. The Management and Prognostic Prediction of Adenocarcinoma of Appendix. Sci Rep. 2016 Dec 16;6:39027. [PMC free article: PMC5159879] [PubMed: 27982068]
- Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB. Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review. Am Surg. 2018 Feb 01;84(2):273-281. [PubMed: 29580358]
- Calis H. Morbidity and Mortality in Appendicitis in the Elderly. J Coll Physicians Surg Pak. 2018 Nov;28(11):875-878. [PubMed: 30369383]
- Keller CA, Dudley RM, Huycke EM, Chow RB, Ali A. Stump appendicitis. Radiol Case Rep. 2022 Jul;17(7):2534-2536. [PMC free article: PMC9118493] [PubMed: 35601384]
- Gorter RR, Eker HH, Gorter-Stam MA, Abis GS, Acharya A, Ankersmit M, Antoniou SA, Arolfo S, Babic B, Boni L, Bruntink M, van Dam DA, Defoort B, Deijen CL, DeLacy FB, Go PM, Harmsen AM, van den Helder RS, Iordache F, Ket JC, Muysoms FE, Ozmen MM, Papoulas M, Rhodes M, Straatman J, Tenhagen M, Turrado V, Vereczkei A, Vilallonga R, Deelder JD, Bonjer J. Diagnosis and management of acute appendicitis. EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-4690. [PMC free article: PMC5082605] [PubMed: 27660247]
- Smith MP, Katz DS, Lalani T, Carucci LR, Cash BD, Kim DH, Piorkowski RJ, Small WC, Spottswood SE, Tulchinsky M, Yaghmai V, Yee J, Rosen MP. ACR Appropriateness Criteria® Right Lower Quadrant Pain–Suspected Appendicitis. Ultrasound Q. 2015 Jun;31(2):85-91. [PubMed: 25364964]
- Schoel L, Maizlin II, Koppelmann T, Onwubiko C, Shroyer M, Douglas A, Russell RT. Improving imaging strategies in pediatric appendicitis: a quality improvement initiative. J Surg Res. 2018 Oct;230:131-136. [PubMed: 30100029]
- Zosimas D, Lykoudis PM, Pilavas A, Burke J, Leung P, Strano G, Shatkar V. Open versus laparoscopic appendicectomy in acute appendicitis: results of a district general hospital. S Afr J Surg. 2018 Jun;56(2):59-62. [PubMed: 30010266]
- Schneuer FJ, Adams SE, Bentley JP, Holland AJ, Huckel Schneider C, White L, Nassar N. A population-based comparison of the post-operative outcomes of open and laparoscopic appendicectomy in children. Med J Aust. 2018 Jul 16;209(2):80-85. [PubMed: 29976133]