Introduction
Appendectomy, the surgical removal of the appendix, is a common procedure performed to treat appendicitis, an inflammation of this small organ located in the abdomen. While generally safe, optimal post-operative care is crucial for patient recovery and to prevent complications. Effective nursing care relies heavily on accurate nursing diagnoses that guide interventions to address patient needs following an appendectomy. This article focuses on key nursing diagnoses relevant to post-operative appendectomy care, aiming to provide a comprehensive guide for nurses to enhance patient outcomes and recovery.
Understanding Appendectomy and Post-Operative Needs
Appendicitis, often caused by an obstruction in the appendix, leads to inflammation, pain, and potential infection. An appendectomy resolves this acute condition. Post-operatively, patients require careful monitoring and management to ensure a smooth recovery. Nursing care plays a pivotal role in this phase, focusing on pain management, preventing infection, promoting fluid balance, ensuring mobility, and addressing patient anxiety. Identifying appropriate nursing diagnoses is the first step in creating an effective care plan.
Key Nursing Diagnoses for Post-Appendectomy Patients
Several nursing diagnoses are pertinent to patients recovering from an appendectomy. These diagnoses help nurses prioritize care and implement targeted interventions.
Acute Pain
Post-operative pain is a primary concern following an appendectomy. The surgical incision and the body’s healing process contribute to pain.
- Defining Characteristics: Patient report of pain, guarding behavior, facial grimacing, changes in vital signs (increased heart rate, blood pressure), restlessness.
- Related Factors: Surgical incision, tissue trauma, inflammatory process.
- Nursing Goal: To effectively manage and reduce pain to a tolerable level, promoting comfort and facilitating recovery.
Risk for Infection
Surgical incisions inherently carry a risk of infection. Post-appendectomy patients, especially those who had a ruptured appendix, are at an increased risk.
- Risk Factors: Surgical incision, break in skin integrity, potential contamination during surgery (especially in cases of ruptured appendix), inadequate wound care, compromised immune system.
- Nursing Goal: To prevent surgical site infection and systemic infection through meticulous wound care, monitoring, and timely intervention.
Risk for Fluid Volume Deficit
Nausea, vomiting, and reduced oral intake post-surgery can lead to fluid volume deficit.
- Risk Factors: Nausea and vomiting (post-anesthesia effects, pain), decreased oral intake (pain, discomfort, NPO status initially), surgical fluid loss.
- Nursing Goal: To maintain adequate fluid balance and prevent dehydration by encouraging oral intake when tolerated, monitoring hydration status, and administering intravenous fluids as prescribed.
Risk for Deep Vein Thrombosis (DVT)
Immobility during the post-operative period increases the risk of DVT.
- Risk Factors: Decreased mobility post-surgery, surgical procedure itself, potential hypercoagulability associated with surgery and inflammation.
- Nursing Goal: To prevent DVT through early ambulation, prophylactic measures like sequential compression devices (SCDs), and patient education on leg exercises and signs of DVT.
Anxiety
Hospitalization, surgery, and pain can contribute to patient anxiety.
- Defining Characteristics: Patient expressing feelings of worry, nervousness, or fear; restlessness, irritability, increased heart rate, difficulty sleeping.
- Related Factors: Unfamiliar hospital environment, surgical procedure, pain, potential for complications, lack of information.
- Nursing Goal: To reduce patient anxiety by providing clear information, emotional support, and creating a calm and reassuring environment.
Nursing Interventions to Improve Post-Operative Care
Based on these key nursing diagnoses, specific interventions can be implemented to enhance post-operative care.
Pain Management Strategies
Effective pain management is paramount for patient comfort and recovery.
- Pain Assessment: Regularly assess pain using a pain scale (e.g., numerical rating scale) to determine pain intensity, location, and quality.
- Pharmacological Interventions: Administer prescribed analgesics (e.g., opioids, NSAIDs) as ordered, ensuring timely administration and monitoring for effectiveness and side effects. Utilize patient-controlled analgesia (PCA) if appropriate.
- Non-Pharmacological Interventions: Implement non-pharmacological pain relief measures such as:
- Positioning: Assist patient to find a comfortable position, often semi-Fowler’s or lateral position.
- Ice packs: Apply ice packs to the incision site to reduce swelling and pain (as prescribed).
- Relaxation techniques: Encourage deep breathing exercises, distraction, and guided imagery.
- Comfort measures: Provide back rubs, ensure a quiet and restful environment.
Infection Prevention and Wound Care
Meticulous wound care and preventive measures are crucial to minimize infection risk.
- Wound Assessment: Regularly assess the surgical incision site for signs of infection (redness, swelling, warmth, pain, drainage). Document wound appearance.
- Wound Care: Follow hospital protocols for wound care, including:
- Dressing changes: Perform dressing changes as ordered, using aseptic technique.
- Incision cleaning: Cleanse the incision site as per protocol, observing for drainage and signs of infection.
- Hygiene: Promote good hygiene practices, including handwashing for healthcare providers and patients. Encourage patients to maintain personal hygiene.
- Antibiotic Administration: Administer prophylactic or therapeutic antibiotics as prescribed, ensuring timely administration and monitoring for allergic reactions.
Fluid and Electrolyte Balance
Maintaining adequate hydration is vital for recovery.
- Fluid Intake Monitoring: Encourage oral fluid intake as soon as tolerated post-operatively. Offer clear liquids initially, progressing to a regular diet as bowel function returns.
- Intravenous Fluids: Administer intravenous fluids as prescribed to maintain hydration, especially if oral intake is limited due to nausea or vomiting.
- Output Monitoring: Monitor urine output, noting volume and characteristics. Assess for signs of dehydration (dry mucous membranes, poor skin turgor, decreased urine output).
- Antiemetics: Administer antiemetics as prescribed to manage nausea and vomiting.
DVT Prevention Measures
Preventing DVT is crucial to avoid serious complications.
- Early Ambulation: Encourage early ambulation as soon as medically stable. Assist patients with getting out of bed and walking short distances, gradually increasing activity levels.
- Leg Exercises: Instruct patients on leg exercises to promote venous circulation (ankle pumps, leg lifts, and rotations).
- Sequential Compression Devices (SCDs): Apply SCDs as prescribed to promote venous return in the lower extremities, especially for patients with limited mobility.
- Anticoagulation: Administer prophylactic anticoagulants (e.g., heparin, enoxaparin) as prescribed for high-risk patients.
Psychological Support and Education
Addressing anxiety and providing education empowers patients in their recovery.
- Anxiety Assessment: Assess patient’s anxiety level and identify stressors.
- Therapeutic Communication: Provide a calm and reassuring presence. Use active listening to address patient concerns and fears.
- Patient Education: Provide clear and concise information about:
- Post-operative care plan and expected recovery timeline.
- Pain management strategies and medication administration.
- Wound care instructions.
- Activity restrictions and recommendations.
- Signs and symptoms of complications to report (infection, DVT, etc.).
- Importance of follow-up appointments.
- Address Concerns: Answer patient questions honestly and address any misconceptions or concerns.
Monitoring and Assessment Post-Appendectomy
Continuous monitoring and assessment are essential to detect and manage potential complications promptly.
Vital Signs and Pain Assessment
- Frequency: Monitor vital signs (temperature, heart rate, blood pressure, respiratory rate) regularly, as per hospital protocol.
- Fever: Monitor for fever, which could indicate infection.
- Tachycardia: Assess for tachycardia, which can be a sign of pain, infection, or fluid volume deficit.
- Pain Reassessment: Regularly reassess pain levels after interventions to evaluate effectiveness and adjust pain management strategies as needed.
Wound Assessment
- Daily Inspection: Inspect the surgical incision site at least once per shift for signs of infection (redness, swelling, warmth, drainage, increased pain).
- Documentation: Document wound appearance, drainage characteristics, and any signs of infection. Report any concerns to the healthcare provider.
Fluid Balance Monitoring
- Intake and Output: Monitor and document fluid intake (oral and intravenous) and output (urine, wound drainage, emesis).
- Daily Weights: Monitor daily weights to assess fluid balance trends.
- Electrolyte Monitoring: Monitor electrolyte levels, especially if patient has been experiencing vomiting or has significant fluid shifts.
Bowel Function
- Bowel Sounds: Auscultate bowel sounds to assess for return of peristalsis.
- Abdominal Distention: Monitor for abdominal distention, which could indicate ileus or bowel obstruction.
- First Bowel Movement: Document the time of first bowel movement post-operatively, as return of bowel function is an important indicator of recovery.
Patient Education and Discharge Planning
Comprehensive patient education and discharge planning are crucial for a successful transition home.
Wound Care at Home
- Incision Care Instructions: Provide detailed instructions on how to care for the surgical incision at home, including:
- Keeping the incision clean and dry.
- Frequency of dressing changes (if applicable).
- Signs and symptoms of infection to watch for and report to the healthcare provider.
- Showering/Bathing Instructions: Provide guidelines on when and how to shower or bathe.
Pain Management at Home
- Medication Regimen: Review prescribed pain medications, dosage, frequency, and potential side effects. Ensure patient understands how to take medications and when to request refills.
- Non-Pharmacological Pain Relief: Reinforce the use of non-pharmacological pain relief measures at home (rest, positioning, ice packs as recommended).
Activity and Diet Recommendations
- Activity Level: Provide guidelines on gradual increase in activity levels, avoiding strenuous activities and heavy lifting for the recommended period (usually 4-6 weeks). Encourage light walking.
- Diet Progression: Advise on dietary progression if applicable, and recommend a balanced diet to promote healing.
- Constipation Prevention: Educate on preventing constipation, especially if opioid pain medications are prescribed. Recommend increased fluid and fiber intake, and stool softeners if necessary.
Follow-up Appointments and When to Seek Help
- Schedule Follow-up: Ensure patient has a scheduled follow-up appointment with the surgeon or primary care provider for wound check and removal of sutures or staples (if applicable).
- Emergency Contact Information: Provide clear instructions on when to seek immediate medical attention and provide contact information for the surgeon’s office and emergency services. Emphasize reporting signs of infection, worsening pain, fever, persistent nausea and vomiting, or signs of DVT (leg swelling, pain, redness).
Conclusion
Nursing diagnoses are fundamental in guiding and structuring post-operative care for appendectomy patients. By focusing on key diagnoses such as acute pain, risk for infection, risk for fluid volume deficit, risk for DVT, and anxiety, nurses can implement targeted interventions to optimize patient outcomes. Comprehensive nursing care, including effective pain management, infection prevention, fluid balance maintenance, DVT prevention, psychological support, and thorough patient education, significantly contributes to a smoother recovery and improved patient well-being after appendectomy. Continuous monitoring and assessment, coupled with proactive nursing interventions, are crucial for ensuring a safe and successful post-operative course.
References
1.Vaos G, Dimopoulou A, Gkioka E, Zavras N. Immediate surgery or conservative treatment for complicated acute appendicitis in children? A meta-analysis. J Pediatr Surg. 2019 Jul;54(7):1365-1371. [PubMed: 30115448]
2.Gignoux B, Blanchet MC, Lanz T, Vulliez A, Saffarini M, Bothorel H, Robert M, Frering V. Should ambulatory appendectomy become the standard treatment for acute appendicitis? World J Emerg Surg. 2018;13:28. [PMC free article: PMC6025707] [PubMed: 29988464]
3.Eng KA, Abadeh A, Ligocki C, Lee YK, Moineddin R, Adams-Webber T, Schuh S, Doria AS. Acute Appendicitis: A Meta-Analysis of the Diagnostic Accuracy of US, CT, and MRI as Second-Line Imaging Tests after an Initial US. Radiology. 2018 Sep;288(3):717-727. [PubMed: 29916776]
4.Kartal İ. Childhood neuroendocrine tumors of the digestive system: A single center experience. Medicine (Baltimore). 2022 Feb 11;101(6):e28795. [PMC free article: PMC8830841] [PubMed: 35147110]
5.Khan MS, Chaudhry MBH, Shahzad N, Tariq M, Memon WA, Alvi AR. Risk of appendicitis in patients with incidentally discovered appendicoliths. J Surg Res. 2018 Jan;221:84-87. [PubMed: 29229158]
6.Stringer MD. Acute appendicitis. J Paediatr Child Health. 2017 Nov;53(11):1071-1076. [PubMed: 29044790]
7.Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015 Sep 26;386(10000):1278-1287. [PubMed: 26460662]
8.Ucar Karabulut K, Erinanc H, Yonar A, Kisinma A, Ucar Y. Correlation of histological diagnosis and laboratory findings in distinguishing acute appendicitis and lymphoid hyperplasia. Ann Surg Treat Res. 2022 Nov;103(5):306-311. [PMC free article: PMC9678668] [PubMed: 36452309]
9.Narula N, Gibbs KE, Kong F, Mukherjee I. Appendiceal Intussusception, Diverticula, and Fecalith Associated With Appendicitis. Am Surg. 2023 Dec;89(12):6257-6259. [PubMed: 36074037]
10.Buckius MT, McGrath B, Monk J, Grim R, Bell T, Ahuja V. Changing epidemiology of acute appendicitis in the United States: study period 1993-2008. J Surg Res. 2012 Jun 15;175(2):185-90. [PubMed: 22099604]
11.Sahm M, Koch A, Schmidt U, Wolff S, Pross M, Gastinger I, Lippert H. [Acute appendicitis – clinical health-service research on the current surgical therapy]. Zentralbl Chir. 2013 Jun;138(3):270-7. [PubMed: 22426968]
12.Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990 Nov;132(5):910-25. [PubMed: 2239906]
13.Téoule P, Laffolie J, Rolle U, Reissfelder C. Acute Appendicitis in Childhood and Adulthood. Dtsch Arztebl Int. 2020 Nov 06;117(45):764-774. [PMC free article: PMC7898047] [PubMed: 33533331]
14.Hamilton AL, Kamm MA, Ng SC, Morrison M. Proteus spp. as Putative Gastrointestinal Pathogens. Clin Microbiol Rev. 2018 Jul;31(3) [PMC free article: PMC6056842] [PubMed: 29899011]
15.Redden M, Ghadiri M. Acute appendicitis with associated trichobezoar of feline hair. J Surg Case Rep. 2022 Mar;2022(3):rjac133. [PMC free article: PMC8963297] [PubMed: 35355580]
16.Correa J, Jimeno J, Vallverdu H, Bizzoca C, Collado-Roura F, Estalella L, Hermoso J, Silva N, Sanchez-Pradell C, Parés D. Correlation between intraoperative surgical diagnosis of complicated acute appendicitis and the pathology report: clinical implications. Surg Infect (Larchmt). 2015 Feb;16(1):41-4. [PubMed: 25761079]
17.Hoffmann JC, Trimborn CP, Hoffmann M, Schröder R, Förster S, Dirks K, Tannapfel A, Anthuber M, Hollerweger A. Classification of acute appendicitis (CAA): treatment directed new classification based on imaging (ultrasound, computed tomography) and pathology. Int J Colorectal Dis. 2021 Nov;36(11):2347-2360. [PubMed: 34143276]
18.Snyder MJ, Guthrie M, Cagle S. Acute Appendicitis: Efficient Diagnosis and Management. Am Fam Physician. 2018 Jul 01;98(1):25-33. [PubMed: 30215950]
19.van Aerts RMM, van de Laarschot LFM, Banales JM, Drenth JPH. Clinical management of polycystic liver disease. J Hepatol. 2018 Apr;68(4):827-837. [PubMed: 29175241]
20.Iwamoto Y, Onishi T, Suzuki R, Arima K, Sugimura Y. Uretero-appendiceal fistula. Int J Urol. 2008 Feb;15(2):180-1. [PubMed: 18269461]
21.Yang HR, Wang YC, Chung PK, Chen WK, Jeng LB, Chen RJ. Laboratory tests in patients with acute appendicitis. ANZ J Surg. 2006 Jan-Feb;76(1-2):71-4. [PubMed: 16483301]
22.Withers AS, Grieve A, Loveland JA. Correlation of white cell count and CRP in acute appendicitis in paediatric patients. S Afr J Surg. 2019 Dec;57(4):40. [PubMed: 31773931]
23.Rao PM. Cecal apical changes with appendicitis: diagnosing appendicitis when the appendix is borderline abnormal or not seen. J Comput Assist Tomogr. 1999 Jan-Feb;23(1):55-9. [PubMed: 10050808]
24.Pooler BD, Repplinger MD, Reeder SB, Pickhardt PJ. MRI of the Nontraumatic Acute Abdomen: Description of Findings and Multimodality Correlation. Gastroenterol Clin North Am. 2018 Sep;47(3):667-690. [PubMed: 30115443]
25.Swenson DW, Ayyala RS, Sams C, Lee EY. Practical Imaging Strategies for Acute Appendicitis in Children. AJR Am J Roentgenol. 2018 Oct;211(4):901-909. [PubMed: 30106612]
26.Kim DW, Suh CH, Yoon HM, Kim JR, Jung AY, Lee JS, Cho YA. Visibility of Normal Appendix on CT, MRI, and Sonography: A Systematic Review and Meta-Analysis. AJR Am J Roentgenol. 2018 Sep;211(3):W140-W150. [PubMed: 30040469]
27.Hwang ME. Sonography and Computed Tomography in Diagnosing Acute Appendicitis. Radiol Technol. 2018 Jan;89(3):224-237. [PubMed: 29298941]
28.Kave M, Parooie F, Salarzaei M. Pregnancy and appendicitis: a systematic review and meta-analysis on the clinical use of MRI in diagnosis of appendicitis in pregnant women. World J Emerg Surg. 2019;14:37. [PMC free article: PMC6647167] [PubMed: 31367227]
29.Awayshih MMA, Nofal MN, Yousef AJ. Evaluation of Alvarado score in diagnosing acute appendicitis. Pan Afr Med J. 2019;34:15. [PMC free article: PMC6859007] [PubMed: 31762884]
30.CODA Collaborative. Flum DR, Davidson GH, Monsell SE, Shapiro NI, Odom SR, Sanchez SE, Drake FT, Fischkoff K, Johnson J, Patton JH, Evans H, Cuschieri J, Sabbatini AK, Faine BA, Skeete DA, Liang MK, Sohn V, McGrane K, Kutcher ME, Chung B, Carter DW, Ayoung-Chee P, Chiang W, Rushing A, Steinberg S, Foster CS, Schaetzel SM, Price TP, Mandell KA, Ferrigno L, Salzberg M, DeUgarte DA, Kaji AH, Moran GJ, Saltzman D, Alam HB, Park PK, Kao LS, Thompson CM, Self WH, Yu JT, Wiebusch A, Winchell RJ, Clark S, Krishnadasan A, Fannon E, Lavallee DC, Comstock BA, Bizzell B, Heagerty PJ, Kessler LG, Talan DA. A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis. N Engl J Med. 2020 Nov 12;383(20):1907-1919. [PubMed: 33017106]
31.Hansson J, Körner U, Khorram-Manesh A, Solberg A, Lundholm K. Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients. Br J Surg. 2009 May;96(5):473-81. [PubMed: 19358184]
32.Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, Rex L, Badume I, Granström L. Appendectomy versus antibiotic treatment in acute appendicitis. a prospective multicenter randomized controlled trial. World J Surg. 2006 Jun;30(6):1033-7. [PubMed: 16736333]
33.Salminen P, Tuominen R, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Hurme S, Mecklin JP, Sand J, Virtanen J, Jartti A, Grönroos JM. Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA. 2018 Sep 25;320(12):1259-1265. [PMC free article: PMC6233612] [PubMed: 30264120]
34.Vons C, Barry C, Maitre S, Pautrat K, Leconte M, Costaglioli B, Karoui M, Alves A, Dousset B, Valleur P, Falissard B, Franco D. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011 May 07;377(9777):1573-9. [PubMed: 21550483]
35.Writing Group for the CODA Collaborative. Zhang IY, Voldal EC, Davidson GH, Liao JM, Thompson CM, Self WH, Kao LS, Cherry-Bukowiec J, Raghavendran K, Kaji AH, DeUgarte DA, Gonzalez E, Mandell KA, Ohe K, Siparsky N, Price TP, Evans DC, Victory J, Chiang W, Jones A, Kutcher ME, Ciomperlik H, Liang MK, Evans HL, Faine BA, Neufeld M, Sanchez SE, Krishnadasan A, Comstock BA, Heagerty PJ, Lawrence SO, Monsell SE, Fannon EEC, Kessler LG, Talan DA, Flum DR. Association of Patient Belief About Success of Antibiotics for Appendicitis and Outcomes: A Secondary Analysis of the CODA Randomized Clinical Trial. JAMA Surg. 2022 Dec 01;157(12):1080-1087. [PMC free article: PMC9535504] [PubMed: 36197656]
36.Sartelli M, Baiocchi GL, Di Saverio S, Ferrara F, Labricciosa FM, Ansaloni L, Coccolini F, Vijayan D, Abbas A, Abongwa HK, Agboola J, Ahmed A, Akhmeteli L, Akkapulu N, Akkucuk S, Altintoprak F, Andreiev AL, Anyfantakis D, Atanasov B, Bala M, Balalis D, Baraket O, Bellanova G, Beltran M, Melo RB, Bini R, Bouliaris K, Brunelli D, Castillo A, Catani M, Che Jusoh A, Chichom-Mefire A, Cocorullo G, Coimbra R, Colak E, Costa S, Das K, Delibegovic S, Demetrashvili Z, Di Carlo I, Kiseleva N, El Zalabany T, Faro M, Ferreira M, Fraga GP, Gachabayov M, Ghnnam WM, Giménez Maurel T, Gkiokas G, Gomes CA, Griffiths E, Guner A, Gupta S, Hecker A, Hirano ES, Hodonou A, Hutan M, Ioannidis O, Isik A, Ivakhov G, Jain S, Jokubauskas M, Karamarkovic A, Kauhanen S, Kaushik R, Kavalakat A, Kenig J, Khokha V, Khor D, Kim D, Kim JI, Kong V, Lasithiotakis K, Leão P, Leon M, Litvin A, Lohsiriwat V, López-Tomassetti Fernandez E, Lostoridis E, Maciel J, Major P, Dimova A, Manatakis D, Marinis A, Martinez-Perez A, Marwah S, McFarlane M, Mesina C, Pędziwiatr M, Michalopoulos N, Misiakos E, Mohamedahmed A, Moldovanu R, Montori G, Mysore Narayana R, Negoi I, Nikolopoulos I, Novelli G, Novikovs V, Olaoye I, Omari A, Ordoñez CA, Ouadii M, Ozkan Z, Pal A, Palini GM, Partecke LI, Pata F, Pędziwiatr M, Pereira Júnior GA, Pintar T, Pisarska M, Ploneda-Valencia CF, Pouggouras K, Prabhu V, Ramakrishnapillai P, Regimbeau JM, Reitz M, Rios-Cruz D, Saar S, Sakakushev B, Seretis C, Sazhin A, Shelat V, Skrovina M, Smirnov D, Spyropoulos C, Strzałka M, Talving P, Teixeira Gonsaga RA, Theobald G, Tomadze G, Torba M, Tranà C, Ulrych J, Uzunoğlu MY, Vasilescu A, Occhionorelli S, Venara A, Vereczkei A, Vettoretto N, Vlad N, Walędziak M, Yilmaz TU, Yuan KC, Yunfeng C, Zilinskas J, Grelpois G, Catena F. Prospective Observational Study on acute Appendicitis Worldwide (POSAW). World J Emerg Surg. 2018;13:19. [PMC free article: PMC5902943] [PubMed: 29686725]
37.Harnoss JC, Zelienka I, Probst P, Grummich K, Müller-Lantzsch C, Harnoss JM, Ulrich A, Büchler MW, Diener MK. Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Systematic Review and Meta-analysis of Controlled Trials (PROSPERO 2015: CRD42015016882). Ann Surg. 2017 May;265(5):889-900. [PubMed: 27759621]
38.Kumar S, Jalan A, Patowary BN, Shrestha S. Laparoscopic Appendectomy Versus Open Appendectomy for Acute Appendicitis: A Prospective Comparative Study. 2016 Jul-Sept.Kathmandu Univ Med J (KUMJ). 14(55):244-248. [PubMed: 28814687]
39.Zani A, Hall NJ, Rahman A, Morini F, Pini Prato A, Friedmacher F, Koivusalo A, van Heurn E, Pierro A. European Paediatric Surgeons’ Association Survey on the Management of Pediatric Appendicitis. Eur J Pediatr Surg. 2019 Feb;29(1):53-61. [PubMed: 30112745]
40.Antonacci N, Ricci C, Taffurelli G, Monari F, Del Governatore M, Caira A, Leone A, Cervellera M, Minni F, Cola B. Laparoscopic appendectomy: Which factors are predictors of conversion? A high-volume prospective cohort study. Int J Surg. 2015 Sep;21:103-7. [PubMed: 26231996]
41.Thambidorai CR, Aman Fuad Y. Laparoscopic appendicectomy for complicated appendicitis in children. Singapore Med J. 2008 Dec;49(12):994-7. [PubMed: 19122949]
42.Siribumrungwong B, Chantip A, Noorit P, Wilasrusmee C, Ungpinitpong W, Chotiya P, Leerapan B, Woratanarat P, McEvoy M, Attia J, Thakkinstian A. Comparison of Superficial Surgical Site Infection Between Delayed Primary Versus Primary Wound Closure in Complicated Appendicitis: A Randomized Controlled Trial. Ann Surg. 2018 Apr;267(4):631-637. [PMC free article: PMC5865487] [PubMed: 28796014]
43.Turk E, Acimis NM, Karaca F, Edirne Y, Tan A, Kilic C. The effect on postoperative pain of pulling the rectus muscle medially during open appendectomy surgery. Minerva Chir. 2014 Jun;69(3):141-6. [PubMed: 24970302]
44.Hucl T, Benes M, Kocik M, Splichalova A, Maluskova J, Krak M, Lanska V, Heczkova M, Kieslichova E, Oliverius M, Spicak J. Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES. Gastroenterol Res Pract. 2016;2016:7320275. [PMC free article: PMC4923531] [PubMed: 27403157]
45.Khashab MA, Kalloo AN. NOTES: current status and new horizons. Gastroenterology. 2012 Apr;142(4):704-710.e1. [PubMed: 22349111]
46.Ahmed K, Wang TT, Patel VM, Nagpal K, Clark J, Ali M, Deeba S, Ashrafian H, Darzi A, Athanasiou T, Paraskeva P. The role of single-incision laparoscopic surgery in abdominal and pelvic surgery: a systematic review. Surg Endosc. 2011 Feb;25(2):378-96. [PubMed: 20623239]
47.Jiang J, Wu Y, Tang Y, Shen Z, Chen G, Huang Y, Zheng S, Zheng Y, Dong R. A novel nomogram for the differential diagnosis between advanced and early appendicitis in pediatric patients. Biomark Med. 2019 Oct;13(14):1157-1173. [PubMed: 31559834]
48.Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E. Appendiceal cancer : a review of the literature. Acta Gastroenterol Belg. 2020 Jul-Sep;83(3):441-448. [PubMed: 33094592]
49.Zhang K, Meyerson C, Kassardjian A, Westbrook LM, Zheng W, Wang HL. Goblet Cell Carcinoid/Carcinoma: An Update. Adv Anat Pathol. 2019 Mar;26(2):75-83. [PubMed: 30601149]
50.Marte A, Sabatino MD, Cautiero P, Accardo M, Romano M, Parmeggiani P. Unexpected finding of laparoscopic appendectomy: appendix MALT lymphoma in children. Pediatr Surg Int. 2008 Apr;24(4):471-3. [PubMed: 17628810]
51.Xie X, Zhou Z, Song Y, Li W, Diao D, Dang C, Zhang H. The Management and Prognostic Prediction of Adenocarcinoma of Appendix. Sci Rep. 2016 Dec 16;6:39027. [PMC free article: PMC5159879] [PubMed: 27982068]
52.Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB. Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review. Am Surg. 2018 Feb 01;84(2):273-281. [PubMed: 29580358]
53.Calis H. Morbidity and Mortality in Appendicitis in the Elderly. J Coll Physicians Surg Pak. 2018 Nov;28(11):875-878. [PubMed: 30369383]
54.Keller CA, Dudley RM, Huycke EM, Chow RB, Ali A. Stump appendicitis. Radiol Case Rep. 2022 Jul;17(7):2534-2536. [PMC free article: PMC9118493] [PubMed: 35601384]
55.Gorter RR, Eker HH, Gorter-Stam MA, Abis GS, Acharya A, Ankersmit M, Antoniou SA, Arolfo S, Babic B, Boni L, Bruntink M, van Dam DA, Defoort B, Deijen CL, DeLacy FB, Go PM, Harmsen AM, van den Helder RS, Iordache F, Ket JC, Muysoms FE, Ozmen MM, Papoulas M, Rhodes M, Straatman J, Tenhagen M, Turrado V, Vereczkei A, Vilallonga R, Deelder JD, Bonjer J. Diagnosis and management of acute appendicitis. EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-4690. [PMC free article: PMC5082605] [PubMed: 27660247]
56.Smith MP, Katz DS, Lalani T, Carucci LR, Cash BD, Kim DH, Piorkowski RJ, Small WC, Spottswood SE, Tulchinsky M, Yaghmai V, Yee J, Rosen MP. ACR Appropriateness Criteria® Right Lower Quadrant Pain–Suspected Appendicitis. Ultrasound Q. 2015 Jun;31(2):85-91. [PubMed: 25364964]
57.Schoel L, Maizlin II, Koppelmann T, Onwubiko C, Shroyer M, Douglas A, Russell RT. Improving imaging strategies in pediatric appendicitis: a quality improvement initiative. J Surg Res. 2018 Oct;230:131-136. [PubMed: 30100029]
58.Zosimas D, Lykoudis PM, Pilavas A, Burke J, Leung P, Strano G, Shatkar V. Open versus laparoscopic appendicectomy in acute appendicitis: results of a district general hospital. S Afr J Surg. 2018 Jun;56(2):59-62. [PubMed: 30010266]
59.Schneuer FJ, Adams SE, Bentley JP, Holland AJ, Huckel Schneider C, White L, Nassar N. A population-based comparison of the post-operative outcomes of open and laparoscopic appendicectomy in children. Med J Aust. 2018 Jul 16;209(2):80-85. [PubMed: 29976133]