Understanding the Common Cancer Diagnosis List in the U.S.

Cancer remains a significant health concern in the United States, impacting millions of lives annually. For those in the automotive repair industry and beyond, understanding the prevalence and impact of different cancers is crucial for community awareness and support. This article delves into the common cancer diagnosis list in the U.S., providing a comprehensive overview of new cases, mortality rates, and key trends. Leveraging data from the American Cancer Society and the National Cancer Institute’s SEER program, we present a detailed analysis of the most frequently diagnosed cancers and their impact on public health.

Cancer Statistics: Key Insights at a Glance

To grasp the scope of cancer in the U.S., it’s essential to look at the overall numbers. Certain cancers are diagnosed far more frequently than others, and similarly, some contribute to a larger proportion of cancer-related deaths. Understanding these common diagnoses is the first step in addressing this complex disease.

Common New Cancer Diagnoses in 2024

In 2024, projections indicate that nearly 50% of all new cancer cases will stem from four primary types: breast, lung and bronchus, prostate, and colorectal cancers. Breast cancer is anticipated to be the most common diagnosis.

Cancer Type Estimated New Cases (2024) Percentage of Total New Cases
Breast 313,510 16%
Prostate 299,010 15%
Lung & Bronchus 234,580 12%
Colon and Rectum 152,810 8%
Other Cancer Types 1,001,230 50%

Leading Causes of Cancer Deaths in 2024

While diagnosis rates are important, mortality statistics reveal the deadliest forms of cancer. Lung and bronchus, colorectal, pancreatic, and breast cancers are predicted to account for almost half of all cancer deaths in 2024.

Cancer Type Estimated Deaths (2024) Percentage of Total Cancer Deaths
Lung & Bronchus 125,070 20%
Colon and Rectum 53,010 9%
Pancreas 51,750 8%
Breast 42,780 7%
Other Cancer Types 339,110 55%

Understanding New Cancer Diagnoses in Detail

Approximately 2.0 million individuals in the U.S. are expected to receive a cancer diagnosis in 2024. Breast cancer stands out as the most prevalent cancer, with an estimated 310,720 diagnoses for women and 2,790 for men. Prostate cancer is the second most common overall and the leading cancer diagnosis among men, with about 299,010 anticipated cases. Lung and bronchus cancer follows as the third most common, with around 234,580 new cases projected.

The top 12 most frequently diagnosed cancer sites encompass over three-quarters of all new cancer cases. For a more extensive list of cancer sites and comparative data, refer to the section on cancer rate comparisons.

Common Cancer Diagnoses by Sex in 2024

Breaking down the Common Diagnosis List by sex reveals some key differences.

Common Cancer Diagnoses in Males

Cancer Type Estimated New Cases
Prostate 299,010
Lung & Bronchus 116,310
Colorectal 81,540
Urinary Bladder 63,070
Melanoma of the Skin 59,170
Kidney and Renal Pelvis 52,380
Non-Hodgkin Lymphoma 44,590
Leukemia 36,450
Pancreas 34,530
Thyroid 12,500
Breast 2,790
Uterus 0

Common Cancer Diagnoses in Females

Cancer Type Estimated New Cases
Breast 310,720
Lung & Bronchus 118,270
Colorectal 71,270
Corpus & Uterus, NOS 67,880
Melanoma of the Skin 41,470
Non-Hodgkin Lymphoma 36,030
Thyroid 31,520
Pancreas 31,910
Kidney and Renal Pelvis 29,230
Leukemia 26,320
Urinary Bladder 20,120
Prostate 0

Source: Cancer Facts & Figures 2024, American Cancer Society (ACS), Atlanta, Georgia, 2024.

Cancer Mortality: Understanding the Deadliest Diagnoses

In 2024, it’s projected that approximately 611,720 cancer-related deaths will occur in the United States. Lung and bronchus cancer is the leading cause of cancer deaths, with an estimated 125,070 fatalities. This is nearly three times higher than colorectal cancer, the second leading cause of cancer mortality, which is expected to cause 53,010 deaths. Pancreatic cancer is the third deadliest, contributing to 51,750 deaths.

The eight deadliest cancer sites are responsible for almost two-thirds of all anticipated cancer deaths. Further details on cancer site comparisons are available in a dedicated section below.

Leading Cancer Deaths by Sex in 2024

Analyzing cancer deaths by sex provides further insight into the impact of different cancer types.

Leading Cancer Deaths in Males

Cancer Type Estimated Deaths
Lung and bronchus 65,790
Prostate 35,250
Colon and rectum 28,700
Pancreas 27,270
Liver & Intrahepatic Bile Duct 19,120
Leukemia 13,640
Non-Hodgkin Lymphoma 11,780
Breast 530

Leading Cancer Deaths in Females

Cancer Type Estimated Deaths
Lung and bronchus 59,280
Breast 42,250
Colon and rectum 24,310
Pancreas 24,480
Liver & Intrahepatic Bile Duct 10,720
Leukemia 10,030
Non-Hodgkin Lymphoma 8,360
Prostate 0

Source: Cancer Facts & Figures 2024, American Cancer Society (ACS), Atlanta, Georgia, 2024.

Comparing Cancer Rates: Incidence, Mortality, and Survival

To effectively compare cancer burdens, statistics are often presented as rates per 100,000 people. Incidence refers to the rate of new cancer cases, while mortality indicates the death rate. These rates are adjusted based on the population group being considered (e.g., rates for females are per 100,000 females in the U.S.).

The following table provides a comprehensive comparison of cancer sites, including estimated new cases and deaths for 2024, age-adjusted rates from recent years, and the five-year relative survival rate, which signifies the percentage of patients surviving five years post-diagnosis.

Learn more about cancer incidence
Learn more about cancer mortality
Learn more about relative survival rate

Site Estimated New Cases (2024) Rate of New Cases (2017–2021) Estimated Deaths (2024) Death Rate (2018–2022) Relative Survival (%) (2014–2020)
Bladder 83,190 18.2 16,840 4.1 78.4
Breast 313,510 68.4 42,780 10.6 91.1
Colon and Rectum 152,810 36.5 53,010 12.9 65.0
Lung and Bronchus 234,580 49.0 125,070 32.4 26.7
Melanoma of the Skin 100,640 21.2 8,290 2.0 94.1
Non-Hodgkin Lymphoma 80,620 18.6 20,140 5.0 74.3
Pancreas 66,440 13.5 51,750 11.2 12.8
Prostate 299,010 116.5 35,250 19.0 97.5
Thyroid 44,020 13.5 2,170 0.5 98.4
Uterus 67,880 28.0 13,250 5.2 80.8
Leukemia 62,770 14.1 23,670 5.9 67.0
Liver and Intrahepatic Bile Duct 41,630 9.4 29,840 6.6 21.7
Ovary 19,680 10.2 12,740 6.0 50.9
Stomach 26,890 7.0 10,880 2.7 36.4
Kidney and Renal Pelvis 81,610 17.2 14,390 3.4 78.1
Oral Cavity and Pharynx 58,450 11.5 12,230 2.6 69.0
Esophagus 22,370 4.2 16,130 3.7 21.6
Brain and Other Nervous System 25,400 6.2 18,760 4.4 33.4
Cervix Uteri 13,820 7.6 4,360 2.2 67.4
Hodgkin Lymphoma 8,570 2.5 910 0.3 88.9
Larynx 12,650 2.6 3,880 0.9 61.5
Myeloma 35,780 7.2 12,540 3.0 61.1
Small Intestine 12,440 2.5 2,090 0.4 70.2
Testis 9,760 5.9 500 0.3 95.0
Anus 10,540 1.9 2,190 0.4 70.6
Bone and Joint 3,970 1.0 2,050 0.5 68.2
Vulva 6,900 2.6 1,630 0.6 69.6

Racial and Ethnic Disparities in Common Cancer Diagnoses

Cancer incidence and mortality rates differ significantly across racial and ethnic groups. The following data highlights these disparities for the most common cancer diagnoses.

New Cancer Cases: Rates by Race and Ethnicity

Cancer Site All Races Hispanic NH AI/AN NH API NH Black NH White
Female Breast 129.4 101.2 113.0 110.3 129.3 139.0
Colon and Rectum 36.5 33.5 49.2 29.4 42.1 36.9
Lung & Bronchus 49.0 26.0 49.2 33.7 52.5 55.4
Prostate 116.5 88.1 76.7 61.4 188.7 114.9

Age-adjusted rates of new cases, SEER 22, 2017–2021. NH = Non-Hispanic, AI/AN = American Indian/Alaska Native, API = Asian & Pacific Islander.

Cancer Death Rates: Disparities by Race and Ethnicity

Mortality rates also exhibit racial and ethnic variations. The graph below illustrates death rates for the five deadliest cancers across different groups.

Cancer Site All Races Hispanic NH AI/AN NH API NH Black NH White
Female Breast 19.3 13.7 17.8 11.9 26.8 19.4
Colon and Rectum 12.9 10.7 17.4 9.1 16.7 12.9
Lung & Bronchus 32.4 14.6 33.3 18.7 34.3 35.4
Pancreas 11.2 8.9 10.6 7.7 13.6 11.4
Prostate 19.0 15.4 19.4 8.8 37.2 18.1

Age-adjusted death rates, U.S., 2018–2022. NH = Non-Hispanic, AI/AN = American Indian/Alaska Native, API = Asian & Pacific Islander.

Trends in Cancer Rates: Progress and Challenges

Analyzing trends in cancer rates over time is crucial for understanding the effectiveness of prevention and treatment efforts.

Recent Trends in New Cancer Case Rates

Between 2017 and 2021, overall new cancer case rates remained stable for both men and women in the U.S. Encouragingly, many common cancers showed a decrease in new cases during this period. Lung and bronchus cancer exhibited the most significant decrease for both sexes.

Trends in New Cancer Cases (Average Annual Percent Change)

Males
Cancer Type AAPC (2017-2021)
Lung and Bronchus -3.7*
Larynx -2.8*
Bladder -1.3*
Brain and Other Nervous System -1.3*
Hodgkin Lymphoma -1.2*
Thyroid -1.1*
Colon and Rectum -1.0*
Esophagus -0.5
Non-Hodgkin Lymphoma -0.4*
Liver and Intrahepatic Bile Duct -0.4
All Sites 0.0
Leukemia 0.1
Oral Cavity and Pharynx 0.6*
Myeloma 0.6*
Testis 0.7*
Stomach 0.7
Kidney and Renal Pelvis 0.8*
Pancreas 0.9*
Melanoma of the Skin 1.0*
Prostate 3.3*
Females
Cancer Type AAPC (2017-2021)
Lung and Bronchus -2.3*
Larynx -2.3*
Thyroid -2.1*
Ovary -1.5*
Bladder -1.3*
Hodgkin Lymphoma -0.9*
Colon and Rectum -0.7*
Cervix Uteri -0.7
Brain and Other Nervous System -0.5*
Non-Hodgkin Lymphoma -0.4*
Esophagus 0.0
Oral Cavity and Pharynx 0.6*
Leukemia 0.6*
All Sites 0.7
Kidney and Renal Pelvis 0.8*
Pancreas 0.9*
Melanoma of the Skin 1.2
Uterus 1.3*
Myeloma 1.4*
Breast 1.4*
Liver and Intrahepatic Bile Duct 1.7*
Stomach 3.3*

AVERAGE ANNUAL PERCENT CHANGE (AAPC) 2017–2021. * AAPC is significantly different from zero (p<0.05). Rates are age-adjusted and adjusted for reporting delay in the registry. The 2020 incidence rate is not used in the calculation of trends. Impact of COVID on SEER Cancer Incidence 2020 data

Recent Trends in Cancer Death Rates

Between 2018 and 2022, overall cancer death rates continued to decline, decreasing by an average of 1.9% per year for men and 1.3% for women. Many common cancers contributed to this positive trend, with significant decreases in death rates. However, testicular cancer in men and uterine cancer in women showed increases in death rates during this period.

Trends in Death Rates (Average Annual Percent Change)

Males
Cancer Type AAPC (2018-2022)
Lung and Bronchus -4.5*
Hodgkin Lymphoma -2.8*
Non-Hodgkin Lymphoma -2.6*
Stomach -2.5*
Myeloma -2.1*
Leukemia -2.0*
All Sites -1.9*
Melanoma of the Skin -1.5*
Kidney and Renal Pelvis -1.5*
Bladder -1.5*
Esophagus -1.3*
Colon and Rectum -1.3*
Liver and Intrahepatic Bile Duct -1.2*
Brain and Other Nervous System -0.9
Larynx -0.7
Thyroid -0.6
Prostate -0.6*
Pancreas 0.3*
Oral Cavity and Pharynx 0.8*
Testis 4.6*
Females
Cancer Type AAPC (2018-2022)
Lung and Bronchus -3.4*
Non-Hodgkin Lymphoma -2.5*
Ovary -2.4*
Larynx -2.2*
Myeloma -2.0*
Stomach -1.8*
Leukemia -1.8*
Colon and Rectum -1.8*
Kidney and Renal Pelvis -1.6*
Bladder -1.6*
Breast -1.5*
All Sites -1.3*
Hodgkin Lymphoma -1.2
Melanoma of the Skin -0.9
Esophagus -0.8
Cervix Uteri -0.7*
Brain and Other Nervous System -0.5
Thyroid 0.1
Pancreas 0.2
Oral Cavity and Pharynx 0.9*
Uterus 1.1*
Liver and Intrahepatic Bile Duct 0.7*

AVERAGE ANNUAL PERCENT CHANGE (AAPC) 2018–2022. *AAPC is significantly different from zero (p<0.05). Rates are age-adjusted.

Learn more about Average annual percent change (AAPC)

Cancer in the Broader Context of U.S. Mortality

Understanding cancer’s impact requires comparing it to other leading causes of death in the U.S.

Cancer Compared to Other Leading Causes of Death (2022)

In 2022, cancer accounted for 18.5% of all deaths in the United States, making it the second leading cause of death after heart disease. Together, heart disease and cancer were responsible for nearly half of all deaths. Notably, cancer is the leading cause of death for individuals under 65 years of age.

Cause of Death Number of Deaths
Heart Disease 702,853
Cancer 608,366
Accidents (Unintentional Injury) 227,020
Stroke (Cerebrovascular) 165,391
Chronic Lower Respiratory Diseases 147,380
Alzheimer’s Disease 120,122
Diabetes 101,207
Nephritis & Nephrosis 57,937
Intentional Self-Harm (Suicide) 49,473
Pneumonia & Influenza 47,051

Trends in U.S. Death Rates: Heart Disease vs. Cancer

Death rates for heart disease have significantly declined across all age groups since 1975. While cancer death rates (Neoplasms) have also decreased slightly overall, the progress has been less pronounced than for heart disease.

Death Rates for Ages Under 65

Year Heart Disease Rate per 100,000 Heart Disease % of Total Deaths Cancer Rate per 100,000 Cancer % of Total Deaths
1975 98.6 26 84.0 22
2022 39.0 16 43.6 18

Death Rates for Ages 65+

Year Heart Disease Rate per 100,000 Heart Disease % of Total Deaths Cancer Rate per 100,000 Cancer % of Total Deaths
1975 2734.9 44 995.2 18
2022 1055.0 23 821.9 19

Source: U.S. Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention. Rates are age-adjusted.

Learn more about Neoplasms

Interactive Cancer Statistics with SEER*Explorer

For more in-depth and customizable cancer statistics, the SEER*Explorer tool offers powerful interactive capabilities.

SEER*Explorer allows you to:

  • Create custom graphs and tables
  • Download data and images
  • Share links to your results

Explore Additional Cancer Statistics with SEER*Explorer

Further Resources on Cancer Surveillance

To delve deeper into cancer surveillance and related topics, consider these resources:

References

The statistics presented in this report are derived from SEER and the CDC’s National Center for Health Statistics. Most data can be accessed through SEER*Explorer. The 2024 estimates for new cases and deaths are projections by the American Cancer Society (ACS).

Suggested Citation

SEER Cancer Statistics Factsheets: Common Cancer Sites. National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/statfacts/html/common.html

This information is in the public domain and can be reproduced without permission, with citation appreciated.

This article provides an overview of the common cancer diagnosis list in the U.S., offering valuable insights into cancer prevalence, mortality, trends, and disparities. Understanding these statistics is crucial for informed discussions and effective strategies to combat cancer.

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