What You Need to Know About CREON Medication
CREON is a prescription medicine used to treat exocrine pancreatic insufficiency (EPI). EPI is a condition where the pancreas does not make enough enzymes to digest food. This can occur due to conditions like cystic fibrosis, chronic pancreatitis, pancreatic cancer, or surgery. Understanding your condition and the role of CREON is crucial for effective management. This guide provides essential safety and usage information to help you navigate your treatment with CREON.
Serious Risk: Fibrosing Colonopathy
It is vital to be aware of a rare but serious bowel condition called fibrosing colonopathy, which has been associated with high doses of pancreatic enzyme products, including CREON. Fibrosing colonopathy involves the thickening and scarring of the colon wall, potentially leading to bowel obstruction. While the risk is rare, it is important to adhere strictly to your healthcare provider’s (HCP) prescribed dosage to minimize this risk.
Seek Immediate Medical Attention
Promptly contact your HCP if you experience any of the following unusual or severe symptoms, as they could be signs of fibrosing colonopathy or other complications:
- Severe stomach area (abdominal) pain
- Bloating
- Difficulty passing stool or constipation
- Nausea
- Vomiting
- Diarrhea
Before Starting CREON: Important Considerations
To ensure CREON is safe and appropriate for you, discuss your complete medical history with your HCP before starting treatment. This includes:
- Pork Allergy: CREON contains pancreatic enzymes derived from pigs. Inform your HCP if you are allergic to pork or pork products.
- Intestinal Issues: Disclose any history of intestinal blockage, scarring, or thickening of your bowel wall (fibrosing colonopathy).
- Gout and Uric Acid Levels: Mention if you have gout, kidney disease, or high blood uric acid (hyperuricemia). CREON can potentially increase uric acid levels in the blood.
- Pregnancy and Breastfeeding: Inform your HCP if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed. The potential risks and benefits of CREON during pregnancy and breastfeeding should be carefully considered.
- Medications: Provide a complete list of all medicines you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. This will help your HCP identify any potential drug interactions.
How to Take CREON Correctly
Follow your HCP’s instructions precisely when taking CREON. Proper administration is essential for optimal effectiveness and safety:
- With Meals and Snacks: Always take CREON with each meal or snack. The enzymes in CREON need to mix with food in your stomach to aid digestion.
- Swallow Whole: Swallow CREON capsules whole with enough liquid to ensure complete ingestion.
- Do Not Crush or Chew: Do not crush or chew CREON capsules or their contents. This can irritate your mouth and alter how the medication works in your body.
- Trouble Swallowing Capsules: If you have difficulty swallowing capsules, consult your HCP or the CREON Medication Guide for alternative administration methods.
Potential Side Effects of CREON
Like all medications, CREON can cause side effects. Be aware of both serious and common side effects:
Serious Side Effects
- Hyperuricemia (Increased Blood Uric Acid): CREON may increase blood uric acid levels, potentially leading to gout or worsening of existing gout. Symptoms of hyperuricemia and gout include joint pain, stiffness, redness, or swelling.
- Allergic Reactions: Although rare, allergic reactions can occur. Seek immediate medical attention if you experience symptoms such as trouble breathing, skin rashes, swollen lips, or itching.
Common Side Effects
The most common side effects of CREON are generally mild and may include:
- Changes in Blood Sugar: Increase (hyperglycemia) or decrease (hypoglycemia) in blood sugar levels.
- Stomach Issues: Stomach pain, frequent or abnormal bowel movements, gas.
- Gastrointestinal: Vomiting.
- Neurological: Dizziness.
- Respiratory: Sore throat, cough.
This is not an exhaustive list of all possible side effects. For more comprehensive information, consult your HCP or pharmacist.
Viral Transmission Risk
CREON and other pancreatic enzyme products are derived from porcine (pig) pancreas. Pigs can carry viruses. While viral transmission from pancreatic enzyme products has never been reported, there is a theoretical risk of viral infection. The manufacturing process for CREON includes steps to minimize this risk.
Reporting Side Effects
You are encouraged to report any negative side effects you experience while taking CREON to the FDA (Food and Drug Administration). You can report side effects online at www.fda.gov/medwatch or by calling 1-800-FDA-1088.
Patient Assistance Programs
If you are struggling to afford your CREON medication, AbbVie, the manufacturer of CREON, may offer patient assistance programs. Visit AbbVie.com/PatientAccessSupport to explore available options and learn more about financial support.
This information provides a summary of important safety and usage guidelines for CREON. It is not a substitute for professional medical advice. Always consult with your healthcare provider for personalized guidance regarding your condition and treatment with CREON.
