Diagnosis code C54.1, as defined within the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM), is a billable and specific code designating Malignant Neoplasm of Endometrium. This code is crucial for medical professionals in documenting and classifying diagnoses related to endometrial cancer in female patients within the United States healthcare system. Effective from October 1, 2024, for the 2025 ICD-10-CM edition, C54.1 remains a vital part of gynecologic oncology and medical coding practices.
Within the realm of ICD-10-CM coding, C54.1 is exclusively applicable to female patients. It is essential to understand that this diagnosis code is part of a larger classification system used for morbidity and mortality statistical purposes, as well as for reimbursement in healthcare settings. Several terms are considered approximate synonyms for Diagnosis C54.1, providing clinicians with varied language to accurately describe the condition. These synonyms include:
- Adenocarcinoma of endometrium
- Cancer of the endometrium
- Cancer of the endometrium, adenocarcinoma
- Cancer of the endometrium, adenosquamous
- Cancer of the endometrium, clear cell
- Cancer of the endometrium, mixed mullerian
- Cancer of the endometrium, papillary serous
- Cancer of the endometrium, stromal sarcoma
- Endometrial cancer with myometrial invasion
- Endometrial carcinosarcoma
- Primary adenosquamous carcinoma of endometrium
- Primary malignant clear cell neoplasm of endometrium
- Primary malignant mixed mullerian neoplasm of endometrium
- Primary malignant neoplasm of endometrium
- Primary malignant neoplasm of endometrium with myometrial invasion
- Primary malignant papillary serous neoplasm of endometrium
- Primary malignant stromal sarcoma of endometrium
Clinically, diagnosis C54.1 refers to a primary or metastatic malignant tumor located in the endometrium. The endometrium is the mucous membrane lining the endometrial cavity, and its involvement by a malignant neoplasm is a significant health concern. The ICD-10-CM system groups C54.1 within specific Diagnostic Related Groups (MS-DRG v42.0), impacting reimbursement processes and healthcare management.
The code C54.1 has been consistently used in the ICD-10-CM system since its introduction in 2016, with no changes through the 2025 edition. This stability ensures consistent data collection and analysis over time. It’s important to note that while C54.1 is the American ICD-10-CM version, international versions of ICD-10 C54.1 may present variations. For accurate coding and clinical documentation within the United States, utilizing diagnosis C54.1 is essential when addressing malignant neoplasms of the endometrium in women. For reimbursement claims with service dates on or after October 1, 2015, the use of ICD-10-CM codes like C54.1 is mandatory.
