Enlarged Prostate Nursing Diagnosis: A Comprehensive Guide

Benign Prostatic Hyperplasia (BPH), commonly known as an enlarged prostate, is a prevalent condition affecting a significant portion of the aging male population. It is characterized by the non-cancerous growth of the prostate gland, leading to lower urinary tract symptoms (LUTS). As the prostate enlarges, it can compress the urethra, causing obstruction and various urinary difficulties. Understanding the nursing diagnosis for enlarged prostate is crucial for effective patient care and management. This article provides a comprehensive guide for nurses to accurately assess, diagnose, and develop care plans for patients with BPH.

Understanding Benign Prostatic Hyperplasia (BPH)

Benign prostatic hyperplasia involves the gradual enlargement of the prostate gland (hyperplasia) caused by an increase in cell size (hypertrophy). This imbalance between cell proliferation and cell death results in an overgrowth of prostate tissue, leading to BPH.

BPH is a widespread condition, affecting approximately half of men by the age of 60. The prostate gland naturally grows as men age. Since the urethra passes through the prostate, enlargement can exert pressure, causing partial or complete blockage. This obstruction leads to difficulties in urination and, if left untreated, can result in complications affecting the kidneys or bladder.

While medical management and surgical interventions are often necessary, nurses play a vital role in patient education and care. Non-invasive methods such as dietary adjustments, weight management, exercise, and pelvic floor training can significantly alleviate BPH symptoms. Nurses are instrumental in educating patients about these lifestyle modifications.

For patients requiring hospitalization for surgical procedures related to BPH, nurses are essential in providing post-operative care. This includes meticulous monitoring of urine output and characteristics, catheter management, and comprehensive discharge instructions to ensure a smooth recovery.

Nursing Assessment for Enlarged Prostate

The nursing process begins with a thorough assessment, encompassing physical, psychosocial, emotional, and diagnostic data collection. In the context of BPH, the nursing assessment focuses on gathering both subjective and objective data to formulate accurate nursing diagnoses.

Review of Health History

1. Evaluating General Symptoms: Enlarged prostate symptoms often develop gradually and worsen over time. Nurses should assess for both early and late symptoms to understand the progression of BPH.

  • Early Symptoms: These initial indicators can significantly impact a patient’s quality of life and are often the first signs that prompt medical attention.

    • Weakened urine stream: Patients may report a decrease in the force and caliber of their urinary stream, making it difficult to empty the bladder effectively.
    • Increased urgency and frequency of urination: A compelling need to urinate more often than usual, both during the day and night, is a hallmark symptom.
    • Increased urination at night (nocturia): Waking up multiple times during the night to urinate disrupts sleep patterns and contributes to fatigue.
    • Inability to start (hesitancy) or continue urination: Difficulty initiating urination or experiencing interruptions in the urine stream are common obstructive symptoms.
    • An unsatisfied feeling of bladder emptying: Despite urinating, patients may feel that their bladder is not completely emptied, leading to repeated attempts to void.
  • Late Symptoms: As BPH progresses, more severe symptoms can emerge, indicating a greater degree of urinary obstruction and potential complications.

    • Dribbling towards the end of urination: Involuntary leakage of urine after voiding, often due to incomplete bladder emptying.
    • Urinary retention: The inability to completely empty the bladder, which can be acute or chronic and may require catheterization.
    • Urinary incontinence: Loss of bladder control, which can manifest as urge, stress, or overflow incontinence.
    • Bladder distention: Accumulation of urine in the bladder due to obstruction, leading to abdominal discomfort and potential complications.
    • Blood in the urine (hematuria): The presence of blood in the urine can be a sign of irritation or damage to the urinary tract.
    • Urinary stasis: Stagnation of urine in the bladder, increasing the risk of infection and stone formation.
    • Urinary tract infections (UTIs): Increased susceptibility to infections due to urinary stasis and incomplete bladder emptying.
    • Painful urination (dysuria): Discomfort or pain during urination, often associated with inflammation or infection.

2. Identifying Risk Factors: Certain factors increase the likelihood of developing BPH, and nurses should assess for these during health history taking.

  • Older age: The prevalence of BPH significantly increases with age, affecting up to 90% of men over 80.
  • Metabolic syndromes: Conditions like glucose intolerance, insulin resistance, and dyslipidemia are linked to an increased risk of BPH.
  • Obesity: Excess body weight, particularly abdominal obesity, is associated with BPH development and symptom severity.
  • Hypertension: High blood pressure has been identified as a risk factor for BPH.
  • Genetic factors: A family history of BPH, especially in first-degree relatives, increases individual risk.
  • Sedentary lifestyle: Lack of physical activity is associated with a higher risk of BPH.

3. Reviewing Medical History: Understanding the patient’s broader medical history can provide context and identify contributing factors to BPH. While the exact cause of prostate enlargement is not fully understood, aging, hormonal changes, and cellular alterations are believed to play roles. It’s noteworthy that men who had testicles removed at an early age do not develop BPH, suggesting a hormonal component.

4. Assessing for Complications: Nurses should be vigilant in assessing for complications arising from an enlarged prostate. Untreated BPH can lead to several health issues.

  • Urinary tract infections (UTIs)
  • Bladder or kidney stones
  • Conditions affecting bladder nerves

5. Reviewing Medications: Certain medications can exacerbate BPH symptoms, and it’s crucial for nurses to review the patient’s medication list.

  • Decongestants (can worsen urinary retention)
  • Antihistamines (can have anticholinergic effects, leading to urinary retention)
  • Diuretics (increase urine production, potentially exacerbating frequency and urgency)
  • Tricyclic antidepressants (can have anticholinergic side effects)

6. Noting Past Surgeries: Previous surgeries, particularly those involving the bladder or pelvic area, can contribute to scarring and potentially influence prostate enlargement or urinary symptoms. Scarring in the bladder from past surgery might contribute to prostate enlargement symptoms.

7. Subjective Questionnaires: Utilizing standardized questionnaires like the American Urological Association Symptom Index/International Prostate Symptom Score (AUASI/IPSS) is essential. This tool quantifies the severity of BPH symptoms based on the patient’s subjective experiences, providing a baseline and tracking changes over time.

8. Fluid Intake Review: Certain beverages can irritate the bladder and worsen BPH symptoms. Alcohol, coffee, and caffeinated sodas can increase diuresis and the urge to urinate, particularly when consumed in excess or close to bedtime. Nurses should inquire about fluid intake patterns, especially the consumption of bladder irritants.

Physical Assessment

1. General Physical Examination: A physical examination provides objective data related to BPH.

  • Palpable bladder (indicating urinary retention)
  • Enlarged or tender lymph nodes in the groin (may suggest infection or other underlying issues)
  • Swollen or tender scrotum (may indicate related conditions or complications)

During the external genitalia examination, nurses should assess for:

  • Discharge from the urethra (suggestive of infection)
  • Narrowing of the urethral opening (meatal stenosis)
  • Phimosis (inability to retract the foreskin)

2. Digital Rectal Examination (DRE): Performing a DRE is a critical component of the physical assessment for BPH. This examination allows the nurse or healthcare provider to assess the prostate gland’s size, shape, and consistency. It helps identify abnormalities such as nodules or areas of induration, which could indicate prostate cancer or other prostate conditions.

Diagnostic Procedures

Diagnostic procedures are essential to confirm the diagnosis of BPH, rule out other conditions, and assess the severity of the condition.

1. Blood Tests: Blood tests provide valuable information about kidney function and prostate-specific antigen levels.

  • Renal function tests (BUN, creatinine): These tests assess kidney function, which can be affected by urinary obstruction caused by BPH. Elevated BUN and creatinine levels may indicate kidney impairment.
  • Prostate-specific antigen (PSA): PSA is a protein produced by the prostate gland. While elevated PSA levels can be indicative of prostate cancer, they can also be elevated in BPH. PSA testing helps in risk stratification and guides further diagnostic evaluation.

2. Urine Tests: Urine analysis is crucial to evaluate for infection, hematuria, and other abnormalities.

  • Urine dipstick: A simple urine dipstick test can detect the presence of infection (leukocytes, nitrites), microscopic hematuria, protein, or glucose in the urine.
  • Post-void residual volume (PVR): Measuring the PVR volume determines the amount of urine remaining in the bladder after urination. A high PVR indicates incomplete bladder emptying, a hallmark of BPH.
  • Frequency-volume chart: This chart records fluid intake and urine output over a period, providing insights into urinary frequency, volume, and nocturnal polyuria.
  • Urodynamic studies: These studies measure the urine flow rate, bladder pressure, and sphincter function, providing a comprehensive assessment of lower urinary tract function and obstruction.

3. Genitourinary System Imaging: Imaging procedures provide detailed visualization of the prostate and urinary tract.

  • Transrectal ultrasound (TRUS): TRUS uses an ultrasound probe inserted into the rectum to measure the prostate size and assess its structure. It is also used to guide prostate biopsies.
  • Cystoscopy: Cystoscopy involves inserting a flexible scope through the urethra to visualize the bladder and urethra directly. It helps rule out other bladder conditions and assess the degree of urethral obstruction.

4. Prostate Biopsy: A prostate biopsy may be necessary to differentiate BPH from prostate cancer, as they can share similar symptoms. Transrectal ultrasonography often guides the biopsy procedure to obtain tissue samples for pathological examination.

Alt text: Transrectal ultrasound (TRUS) procedure for prostate assessment, showing ultrasound probe insertion and image display.

Nursing Interventions for Enlarged Prostate

Nursing interventions are crucial for managing BPH symptoms, improving patient quality of life, and preventing complications.

Managing BPH

1. Addressing the Underlying Cause: While BPH is not always preventable, managing contributing factors and adopting healthy lifestyle habits can mitigate symptoms. For patients with mild symptoms, a “watchful waiting” approach combined with lifestyle modifications may be sufficient. This includes:

  • Avoiding fluids before bedtime to reduce nocturia.
  • Moderating consumption of bladder irritants like caffeine and alcohol.
  • Regular exercise and weight management.

2. Medication Administration: Pharmacological management is a cornerstone of BPH treatment. Nurses are responsible for administering medications, educating patients about their purpose and side effects, and monitoring their effectiveness. Common medications include:

  • Alpha-blockers (doxazosin, prazosin, terazosin, tamsulosin): These medications relax the smooth muscles of the prostate and bladder neck, improving urine flow and reducing obstruction symptoms.
  • 5-alpha reductase inhibitors (finasteride, dutasteride): These drugs reduce the size of the prostate gland by blocking the conversion of testosterone to dihydrotestosterone (DHT), a hormone that contributes to prostate growth.
  • Combination therapy: In some cases, combining alpha-blockers and 5-alpha reductase inhibitors may provide synergistic symptom relief.
  • Phosphodiesterase-5 inhibitors (tadalafil): Tadalafil, commonly used for erectile dysfunction, can also help relieve BPH symptoms, particularly in men who experience both conditions.

3. Alternative Medicine Considerations: Some patients explore alternative and complementary therapies for BPH. Nurses should be aware of commonly used herbal remedies and plant-derived compounds, while emphasizing the importance of discussing these with healthcare providers to ensure safety and efficacy.

  • Saw palmetto
  • African plum tree extract (Pygeum africanum)
  • Rye grass pollen
  • Stinging nettle
  • Pumpkin seeds

4. Surgical Intervention Preparation: When medical management fails to provide adequate relief, or in cases of severe complications, surgery may be necessary. Transurethral Resection of the Prostate (TURP) remains the gold standard surgical treatment for BPH-related bladder outlet obstruction (BOO). Reasons for surgical intervention include:

  • Urinary retention
  • Failed voiding trials
  • Recurrent hematuria
  • Recurrent urinary tract infections
  • Kidney obstruction
  • Failure of medical treatment
  • Financial constraints related to long-term medical therapies

5. Minimally Invasive Procedures: Advances in technology have led to various minimally invasive procedures for BPH treatment. These procedures generally use heat or other energy forms to destroy excess prostate tissue, offering less invasive alternatives to TURP. They often involve milder anesthesia and reduced recovery times.

  • Transurethral incision of the prostate (TUIP)
  • Laser prostatectomy (various laser types)
  • Transurethral needle ablation (TUNA)
  • High-intensity focused ultrasound (HIFU) therapy
  • Water vapor thermal therapy (Rezum)
  • Waterjet ablation therapy (Aquablation)
  • Prostatic urethral lift (PUL) (UroLift)

6. Prostate Removal (Prostatectomy): In cases of very large prostates, open or robot-assisted prostatectomy (prostate removal) may be required. This is a more invasive surgical approach but can be necessary for significant prostate enlargement.

7. Catheter Care: Catheter care is essential for patients with urinary catheters, whether intermittent, indwelling, or suprapubic. Nurses are responsible for maintaining catheter patency, preventing infection, and providing patient education on catheter management.

8. Continuous Bladder Irrigation (CBI): Following TURP, CBI is commonly used to prevent blood clot formation in the bladder and maintain urine flow. Nurses titrate the saline irrigation solution to keep the urine light pink to clear, ensuring optimal bladder drainage and preventing obstruction from clots.

Alt text: Diagram illustrating continuous bladder irrigation (CBI) setup post-TURP, showing saline inflow and urine outflow.

Preventing BPH Progression and Complications

Lifestyle modifications play a significant role in managing BPH symptoms and potentially slowing disease progression. Nurses are key educators in promoting these preventative measures.

1. Promoting an Active Lifestyle: Regular physical activity has numerous health benefits, including potential benefits for prostate health. Studies suggest that vigorous exercise may be associated with better outcomes in men with early-stage prostate cancer and potentially beneficial for BPH as well.

2. Pelvic Muscle Exercises: Pelvic floor exercises, also known as Kegel exercises, can strengthen the muscles involved in bladder control and urinary function. Nurses should instruct patients on how to perform Kegel exercises correctly:

  • Identify pelvic floor muscles (muscles used to stop urine flow).
  • Clench these muscles as if holding back urine.
  • Hold for a few seconds, then relax.
  • Repeat in sets of 10, three times a day.

3. Weight Management: Obesity, particularly abdominal obesity, is linked to increased BPH risk and symptom severity. Weight loss through a balanced diet and regular exercise can be beneficial.

4. Diet Modifications: Dietary changes can positively impact BPH symptoms. A diet low in fat and red meat, and high in protein and vegetables may reduce the risk of BPH-related symptoms. Encourage consumption of fruits, vegetables, and whole grains.

5. Limiting Bladder Irritants: Caffeine and alcohol can irritate the bladder, increase urine production, and worsen urinary symptoms. Reducing or avoiding these substances, especially in the evening, can be helpful.

6. Regular and Scheduled Urination: Establishing healthy bathroom habits can improve bladder control and reduce urinary stasis.

  • Urinate promptly when the urge arises.
  • Schedule regular bathroom breaks, even if the urge is not strong.
  • Practice double voiding: urinate, wait a few moments, and urinate again to maximize bladder emptying.

7. Medication Alternatives: If certain medications, such as decongestants or antihistamines, are exacerbating urinary symptoms, nurses should facilitate discussions with healthcare providers about potential alternatives that have fewer urinary side effects.

Nursing Care Plans for Enlarged Prostate

Nursing care plans provide a structured framework for prioritizing assessments and interventions for patients with BPH. They guide both short-term and long-term care goals. Common nursing diagnoses associated with BPH include acute pain, disturbed sleep pattern, risk for deficient fluid volume, risk for urinary tract injury, and urinary retention.

Acute Pain

Acute pain related to BPH can arise from bladder distention, renal colic, urinary tract infections, or post-procedural discomfort.

Nursing Diagnosis: Acute Pain

Related to:

  • Distended bladder
  • Renal colic
  • Urinary tract infection
  • Catheter insertion
  • Surgical procedures

As evidenced by:

  • Complaints of bladder or rectal spasm
  • Facial grimacing
  • Distraction behaviors
  • Restlessness
  • Altered vital signs
  • Diaphoresis

Expected Outcomes:

  • Patient will verbalize relief from bladder or urinary tract pain.
  • Patient will demonstrate interventions to ease discomfort.

Assessments:

  1. Pain Assessment: Conduct a comprehensive pain assessment, including location, intensity, quality, aggravating/relieving factors, and impact on function. Inadequate pain assessment can lead to poor pain management.
  2. Triggering Factors: Identify factors that trigger or worsen pain, such as movement, urination, or ejaculation.
  3. Urinalysis Review: Review urinalysis results to assess for urinary tract infection, which can contribute to pain.

Interventions:

  1. Sitz Baths and Warm Soaks: Encourage sitz baths or warm soaks for 20 minutes several times a day to soothe perineal discomfort and relax prostate and surrounding muscles.
  2. Catheter Securement: Ensure proper securement of urinary catheters to prevent traction and pain at the penile-scrotal junction.
  3. Antispasmodics: Administer antispasmodics as prescribed to relieve bladder spasms associated with catheter irritation.
  4. Prostate Massage: Prostate massage (performed by a healthcare professional or self-administered as instructed) may help relieve fluid buildup and inflammation, reducing pain.
  5. Pain Medication: Administer analgesics, including narcotics if necessary, as prescribed for pain relief, particularly post-operatively.

Disturbed Sleep Pattern

Nocturia, a common symptom of BPH, significantly disrupts sleep patterns.

Nursing Diagnosis: Disturbed Sleep Pattern

Related to:

  • Nocturia
  • Pain caused by BPH
  • Increased urgency to urinate
  • Increased frequency of urination

As evidenced by:

  • Insomnia
  • Irregular sleeping pattern
  • Inadequate sleep quality
  • Bladder pain
  • Bladder irritability
  • Frequent urination
  • Restlessness

Expected Outcomes:

  • Patient will verbalize restful sleep.
  • Patient will demonstrate a calm and well-rested appearance.
  • Patient will achieve at least 8 hours of sleep nightly (or patient-specific sleep goal).

Assessments:

  1. Nocturia Documentation: Ask the patient to document the frequency of nighttime urination to quantify nocturia and identify patterns.
  2. Sleep Habits Assessment: Assess sleep habits and routines to identify factors that may interfere with sleep.
  3. Medication Review: Review medications, particularly diuretics, and adjust timing if possible to minimize nighttime diuresis.

Interventions:

  1. Fluid Intake Management: Advise limiting fluid intake 2-4 hours before bedtime. Encourage adequate fluid intake during the day, especially water, to prevent dehydration. Emphasize limiting alcohol and caffeine intake, especially in the evening.
  2. Desmopressin Administration: Administer desmopressin (synthetic vasopressin) as prescribed to reduce nighttime urine production in select patients with nocturia.
  3. Prostate Shrinking Medications: Administer 5-alpha reductase inhibitors like finasteride to reduce prostate size and potentially nocturia over time.
  4. Compression Stockings/Leg Elevation: During the day, encourage leg elevation or compression stockings to promote fluid circulation and reduce fluid retention in the legs, which can minimize nighttime urination.

Risk for Deficient Fluid Volume

Post-obstructive diuresis following BPH treatment can lead to fluid volume deficit.

Nursing Diagnosis: Risk for Deficient Fluid Volume

Related to:

  • Disease process (post-obstructive diuresis)
  • Polyuria
  • Insufficient fluid intake
  • Problems associated with fluid elimination (CKD, CHF)

As evidenced by:

Risk diagnoses are not evidenced by signs and symptoms as the problem has not yet occurred. Nursing interventions are aimed at prevention.

Expected Outcomes:

  • Patient will maintain a urine output of at least 0.5mL/kg/hr (or individualized target).
  • Patient will remain free from signs of dehydration (altered mental status, poor skin turgor, vital sign changes).

Assessments:

  1. Hydration Status and Urine Output: Closely monitor intake and output, particularly in the post-obstructive period, to detect and manage diuresis.
  2. Diagnostic Studies Review: Review uroflowmetry, cystoscopy, and TRUS results to understand the degree of obstruction and guide treatment.
  3. Post-Void Residual Assessment: Assess PVR volume, as higher PVR may predict increased risk of post-obstructive diuresis.
  4. Laboratory Monitoring: Monitor renal function (BUN, creatinine) and electrolytes (sodium, potassium) to detect and manage imbalances related to diuresis.

Interventions:

  1. Bladder Decompression: Ensure bladder decompression via urinary catheter to relieve obstruction and allow for accurate urine output monitoring.
  2. Close Monitoring: Monitor lab values, urine samples (sodium, potassium, osmolality), and vital signs frequently (at least every 12 hours or more often as needed) to detect and manage fluid and electrolyte imbalances.
  3. Fluid Replacement: Encourage oral fluid replacement for alert and oriented patients. Administer IV fluids as prescribed for patients unable to maintain oral intake or with significant fluid deficits. Avoid excessive fluid administration, which can exacerbate diuresis.
  4. Continuous Urine Output Monitoring: Monitor urine output hourly. Output exceeding 200 mL/hour for two consecutive hours may indicate post-obstructive diuresis and requires close management.

Risk for Urinary Tract Injury

Urinary obstruction from BPH and catheterization procedures increase the risk of urinary tract injury.

Nursing Diagnosis: Risk for Urinary Tract Injury

Related to:

  • Urinary tract obstruction
  • Enlarged prostate
  • Disease process
  • Catheter insertion

As evidenced by:

Risk diagnoses are not evidenced by signs and symptoms as the problem has not yet occurred. Nursing interventions are aimed at prevention.

Expected Outcomes:

  • Patient will remain free from signs of urinary tract injury (hematuria, pain).
  • Patient will experience unobstructed urination with adequate urine output (0.5–1.0 mL/kg/hr or individualized target).

Assessments:

  1. Urinary Elimination Patterns: Monitor and document urinary elimination patterns, including frequency, odor, consistency, volume, and color, to detect changes indicative of injury or complications.
  2. Laboratory Values: Monitor CBC, urinalysis, and serum creatinine levels to assess for infection, hematuria, and renal function.

Interventions:

  1. Bladder Training: Instruct patients on bladder training techniques (timed voiding every 2-3 hours) to reduce urinary stasis and retention.
  2. Adequate Fluid Intake: Encourage adequate fluid intake to prevent urinary stasis and reduce the risk of UTIs and stone formation, which can contribute to urinary tract injury.
  3. Aseptic Catheter Insertion: Utilize aseptic technique during catheter insertion to minimize the risk of infection and urethral trauma. Select appropriate catheter size and type (e.g., coudé catheter may be needed for enlarged prostate) and ensure proper lubrication and gentle insertion.
  4. Avoid Bladder Irritants: Advise patients to avoid bladder irritants like alcohol and caffeine, which can exacerbate prostatic symptoms and increase the risk of bladder distention and urinary tract injury.

Urinary Retention

Urinary retention is a common and expected finding in BPH.

Nursing Diagnosis: Urinary Retention

Related to:

  • Enlargement of the prostate
  • Blockage of urine flow
  • Inability of bladder muscles to contract adequately

As evidenced by:

  • Urinary frequency
  • Urinary hesitancy
  • Failure to empty the bladder
  • Dribbling urine
  • Overflow incontinence
  • Sensation of bladder fullness
  • Dysuria
  • Bladder distention
  • Residual urine

Expected Outcomes:

  • Patient will not experience a post-void residual greater than 50 mL (or individualized target).
  • Patient will verbalize a reduction in hesitancy, dribbling, and bladder fullness.

Assessments:

  1. Urine Elimination Patterns: Assess and document changes in urination patterns, including frequency, urgency, weak stream, hesitancy, dribbling, and nocturia.
  2. Bladder Palpation: Palpate the bladder to assess for distention, which indicates urinary retention.
  3. Urine Characteristics: Observe urine characteristics, noting color, odor, and presence of blood, which may indicate infection or other complications.
  4. Additional Signs and Symptoms: Assess for associated symptoms such as hypertension, edema, changes in mentation, bloody urine or semen, painful ejaculation, and lower back, hip, pelvis, or thigh pain.

Interventions:

  1. Post-Void Residual (PVR) Volume Assessment: Measure PVR volume using a bladder scanner after voiding to quantify urinary retention.
  2. Catheterization: Perform intermittent or indwelling catheterization as needed to relieve urinary retention and prevent complications. Consult a urologist if catheter insertion is difficult due to prostate enlargement; a guidewire may be required.
  3. Muscle Relaxation Medications: Administer alpha-adrenergic antagonists as prescribed to relax prostate and bladder neck muscles, improving urine flow.
  4. Antibiotics: Administer antibiotics as prescribed if urinary retention is complicated by urinary tract infection.
  5. Urology Referral: Refer patients with significant urinary retention to a urologist for specialized management and further evaluation.

References

  • Национальный институт диабета и болезней органов пищеварения и почек (NIDDK). (n.d.). Доброкачественная гиперплазия предстательной железы (ДГПЖ).
  • Mayo Clinic. (2023). Увеличенная простата (доброкачественная гиперплазия предстательной железы) – Диагностика и лечение – Mayo Clinic.
  • Cleveland Clinic. (2021). Увеличение простаты (ДГПЖ): симптомы, причины, лечение – Cleveland Clinic.
  • WebMD. (n.d.). Увеличение простаты: симптомы, причины и лечение.
  • American Urological Association. (2023). Доброкачественная гиперплазия предстательной железы (ДГПЖ).

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