Nursing Care Diagnosis for Diabetes Mellitus: A Comprehensive Guide for Healthcare Professionals

Introduction

Diabetes mellitus is a widespread and growing global health concern, characterized by persistent hyperglycemia. Type 2 diabetes mellitus (T2DM) is the most common form, accounting for approximately 90% of all diabetes cases, while other types include type 1 diabetes, gestational diabetes, and drug-induced diabetes. Uncontrolled diabetes can lead to severe complications affecting nearly every organ system, potentially resulting in life-threatening conditions. This article provides an in-depth review of nursing diagnoses, etiology, risk factors, assessment strategies, evaluation methods, medical and nursing management, and critical considerations for nurses caring for patients with diabetes mellitus, particularly focusing on type 2 diabetes.

Nursing Diagnoses for Diabetes Mellitus

Nurses play a crucial role in the management of diabetes, and accurate nursing diagnoses are fundamental to developing effective care plans. For patients diagnosed with diabetes mellitus, several nursing diagnoses may be relevant, depending on the individual’s condition and complications. These can include:

  • Risk for Unstable Blood Glucose Level: This diagnosis is pertinent for all diabetic patients due to the inherent challenges in maintaining glycemic control. Fluctuations between hyperglycemia and hypoglycemia can be dangerous and require careful monitoring and management.
  • Deficient Knowledge: Diabetes management requires significant patient involvement. Lack of understanding about the disease process, treatment regimens, self-monitoring techniques, and lifestyle modifications is a major barrier to effective diabetes care.
  • Imbalanced Nutrition: More Than Body Requirements/Less Than Body Requirements: Diabetes significantly impacts metabolism and nutritional needs. Patients may struggle with dietary adherence, leading to nutritional imbalances.
  • Risk for Infection: Hyperglycemia impairs immune function, increasing susceptibility to infections, particularly in the presence of wounds or compromised circulation.
  • Impaired Skin Integrity: Diabetic patients are prone to skin complications due to neuropathy, poor circulation, and impaired wound healing. This diagnosis is relevant when superficial skin issues like rashes or lesions are present.
  • Impaired Tissue Integrity: This is a more severe diagnosis than impaired skin integrity, indicating deeper tissue damage, often associated with diabetic foot ulcers or other non-healing wounds.
  • Risk for Peripheral Neurovascular Dysfunction: Diabetes-related neuropathy and vascular disease can compromise nerve and blood vessel function in the extremities, leading to pain, numbness, and impaired mobility.
  • Risk for Injury: Neuropathy, vision changes (like blurred vision or diabetic retinopathy), and episodes of hypoglycemia or hyperglycemia can increase the risk of falls and other injuries.
  • Fluid Volume Deficit: Extreme hyperglycemia, such as in diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS), can lead to significant fluid loss and dehydration, requiring urgent intervention.
  • Ineffective Health Maintenance: Managing diabetes is a lifelong commitment. Patients may struggle with adherence to medication, lifestyle modifications, and recommended monitoring, leading to ineffective health maintenance.

It’s important to note that these diagnoses are not exhaustive, and the specific nursing diagnoses should be tailored to each patient’s individual needs and presentation. A thorough assessment is crucial to identify the most appropriate diagnoses and guide the development of a personalized care plan.

Causes of Diabetes Mellitus

Understanding the underlying causes of diabetes is essential for effective management and patient education. The etiology differs between the main types:

  • Type 1 Diabetes Mellitus (T1DM): T1DM is an autoimmune disease. The body’s immune system mistakenly attacks and destroys the insulin-producing beta cells in the islets of Langerhans within the pancreas. This results in an absolute deficiency of insulin.
  • Type 2 Diabetes Mellitus (T2DM): T2DM is characterized by insulin resistance, where the body’s cells do not respond effectively to insulin. Over time, the pancreas may also lose its ability to produce sufficient insulin. While the exact cause isn’t fully understood, genetic predisposition and lifestyle factors play significant roles.
  • Drug-Induced Diabetes: Certain medications, particularly corticosteroids, can induce diabetes. While diabetes may resolve upon discontinuation of the medication in some cases, it can persist in others. Other medications can also contribute, and healthcare providers should be vigilant about monitoring glucose levels in patients taking potentially diabetogenic drugs.

Risk Factors for Type 2 Diabetes Mellitus

Identifying risk factors for T2DM is critical for proactive screening and preventative measures. Major risk factors include:

  • Ethnicity: Certain ethnic groups have a higher prevalence of T2DM, including Native Americans, African Americans, Hispanics, Asian Americans, and Pacific Islanders. Genetic and sociocultural factors may contribute to these disparities.
  • Age: The risk of T2DM increases significantly with age, particularly after 40 years old. This is partly due to age-related declines in insulin sensitivity and beta-cell function.
  • Overweight and Obesity: Excess body weight, especially abdominal obesity, is a major risk factor for insulin resistance and T2DM.
  • Family History of Diabetes: Having a first-degree relative (parent, sibling) with T2DM significantly increases an individual’s risk, highlighting the genetic component of the disease.
  • History of Cardiovascular Disease: Conditions like heart disease and hypertension are often associated with insulin resistance and share common risk factors with T2DM.
  • Hyperlipidemia: Abnormal lipid levels (high cholesterol and triglycerides) are linked to insulin resistance and increased diabetes risk.
  • History of Gestational Diabetes (GDM): Women who have had GDM during pregnancy have a substantially increased lifetime risk of developing T2DM later in life.
  • Sedentary Lifestyle: Lack of physical activity contributes to insulin resistance and weight gain, increasing diabetes risk.
  • Polycystic Ovary Syndrome (PCOS): PCOS is a hormonal disorder in women that is often associated with insulin resistance and increased risk of T2DM.
  • Prediabetes: Individuals with prediabetes (impaired glucose tolerance or impaired fasting glucose) are at high risk of progressing to T2DM if lifestyle interventions are not implemented.

Assessment of Diabetes Mellitus

A comprehensive assessment is essential for both diagnosing diabetes and managing the condition effectively. Assessment includes:

  • History:

    • Risk Factor Assessment: Inquire about family history of diabetes, ethnicity, age, history of GDM, cardiovascular disease, hyperlipidemia, and lifestyle factors.
    • Symptom Review: Ask about classic diabetes symptoms such as polyuria (frequent urination), polydipsia (excessive thirst), polyphagia (increased hunger), unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. However, many individuals with T2DM, especially in the early stages, may be asymptomatic.
  • Physical Examination:

    • Body Mass Index (BMI) Calculation: Calculate BMI to assess weight status. A BMI ≥ 25 kg/m² is considered overweight, and ≥ 30 kg/m² is obese, both increasing diabetes risk.
    • Acanthosis Nigricans: In pediatric and adult patients, inspect for acanthosis nigricans, a skin condition characterized by dark, velvety patches, often in skin folds, which can be a sign of insulin resistance.
  • For Patients with Diagnosed Diabetes:

    • Skin Assessment: Inspect skin, particularly feet and lower extremities, for wounds, ulcers, infections, and signs of poor circulation.
    • Eye Examination: Ideally, a dilated eye exam by an ophthalmologist is needed to assess for diabetic retinopathy. Nurses may perform a basic eye exam and note any visual complaints for referral.
    • Neurological Assessment: Perform microfilament testing to assess for peripheral neuropathy, checking sensation in the feet and lower extremities. Assess for other signs of neuropathy, such as pain, numbness, or tingling.
    • Cardiovascular Assessment: Check blood pressure, heart rate, and listen to heart sounds. Assess for signs of peripheral artery disease (PAD), such as diminished pulses in the feet.

Evaluation and Diagnostic Testing

Laboratory testing is crucial for diagnosing and monitoring diabetes.

  • Fasting Plasma Glucose (FPG): A fasting blood glucose level of 126 mg/dL (7.0 mmol/L) or greater on more than one occasion is diagnostic of diabetes.
  • Glycated Hemoglobin (HbA1c): HbA1c reflects average blood glucose levels over the past 2-3 months. An HbA1c of 6.5% or higher is diagnostic of diabetes. An HbA1c between 5.7% and 6.4% indicates prediabetes. HbA1c is also used for monitoring long-term glycemic control in diagnosed patients.
  • Oral Glucose Tolerance Test (OGTT): Involves measuring blood glucose 2 hours after drinking a sugary drink. A 2-hour plasma glucose of 200 mg/dL (11.1 mmol/L) or greater is diagnostic of diabetes. OGTT is less commonly used for routine diagnosis than FPG or HbA1c.
  • Random Plasma Glucose: A random blood glucose level of 200 mg/dL (11.1 mmol/L) or greater in a patient with classic symptoms of hyperglycemia can also diagnose diabetes.

Screening recommendations vary, but generally, adults over 40-45 years old, or younger adults with risk factors, should be screened for diabetes.

Medical Management of Type 2 Diabetes Mellitus

The primary goals of medical management are to achieve and maintain optimal glycemic control, prevent complications, and improve quality of life. Management strategies include:

  • Lifestyle Modification: This is the cornerstone of T2DM management and includes:

    • Medical Nutrition Therapy (MNT): Individualized dietary plans focusing on balanced macronutrient intake, portion control, and healthy food choices. Emphasis is placed on limiting processed foods, sugary drinks, and unhealthy fats.
    • Regular Physical Activity: Aim for at least 150 minutes of moderate-intensity aerobic activity per week, plus muscle-strengthening exercises. Exercise improves insulin sensitivity and helps with weight management.
    • Weight Management: For overweight or obese individuals, even modest weight loss (5-10% of body weight) can significantly improve glycemic control and reduce diabetes risk factors.
    • Smoking Cessation: Smoking exacerbates diabetes complications and increases cardiovascular risk.
  • Pharmacological Therapy: When lifestyle modifications alone are insufficient to achieve target glucose levels, medications are necessary.

    • Metformin: Often the first-line medication for T2DM. It works by reducing hepatic glucose production and improving insulin sensitivity.
    • Other Oral Antidiabetic Agents: Various classes of oral medications are available, including sulfonylureas, thiazolidinediones (TZDs), dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists (some GLP-1 RAs are injectable but are often considered in the oral agent category when discussing initial pharmacotherapy). The choice of medication depends on individual patient factors, comorbidities, and treatment goals.
    • Insulin Therapy: Insulin may be required for T2DM, especially as the disease progresses and insulin production declines. Insulin is categorized by onset and duration of action (rapid-acting, short-acting, intermediate-acting, long-acting, and premixed formulations) to mimic physiological insulin secretion.
  • Management of Comorbidities: Many individuals with T2DM have co-existing conditions like hypertension, hyperlipidemia, and cardiovascular disease. Managing these comorbidities is essential to reduce overall cardiovascular risk.

Nursing Management of Type 2 Diabetes Mellitus

Nurses are integral to diabetes care, providing education, support, and direct patient care. Key aspects of nursing management include:

  • Blood Glucose Monitoring:

    • Inpatient Monitoring: Regular blood glucose monitoring is essential for hospitalized patients to detect and manage hyperglycemia and hypoglycemia. Nurses must be proficient in blood glucose testing procedures and interpreting results.
    • Patient Education on Self-Monitoring of Blood Glucose (SMBG): Educate patients on how to perform SMBG accurately, interpret readings, and understand when and how often to test. Tailor SMBG frequency to individual needs and treatment regimens.
  • Hypoglycemia and Hyperglycemia Management:

    • Hypoglycemia Recognition and Treatment: Nurses must be able to recognize the signs and symptoms of hypoglycemia (e.g., sweating, tremors, dizziness, confusion, loss of consciousness). Immediate treatment is crucial. For conscious patients, oral glucose (glucose tablets, juice) is administered. For unconscious patients, intravenous dextrose or glucagon injection may be necessary, following established protocols.
    • Hyperglycemia Recognition and Management: Recognize symptoms of hyperglycemia (e.g., increased thirst, frequent urination, fatigue, blurred vision). For extreme hyperglycemia (e.g., blood glucose > 600 mg/dL), prompt medical intervention is required, potentially including intravenous fluids, insulin, and electrolyte replacement in an intensive care setting.
  • Patient Education: Comprehensive patient education is paramount and includes:

    • Diabetes Disease Process: Explain the pathophysiology of diabetes, including insulin resistance and the effects of hyperglycemia on the body.
    • Medication Management: Educate on prescribed medications, including dosage, administration technique (especially for insulin injections), timing, side effects, and importance of adherence.
    • Dietary Management: Provide guidance on healthy eating, carbohydrate counting (if applicable), portion control, and making healthy food choices. Refer patients to a registered dietitian for individualized MNT.
    • Exercise Recommendations: Explain the benefits of regular physical activity and provide recommendations tailored to the patient’s abilities and preferences.
    • Foot Care: Educate on daily foot inspections, proper foot hygiene, appropriate footwear, and recognizing signs of foot problems.
    • Sick Day Management: Instruct patients on how to manage their diabetes during illness, including adjusting medication and monitoring glucose more frequently.
    • Complication Prevention: Educate on risk factors for complications and strategies for prevention, such as blood glucose control, blood pressure management, and smoking cessation.
    • Self-Management Skills: Teach skills such as insulin injection technique, SMBG, and problem-solving for common diabetes-related issues.
  • Complication Assessment: Regularly assess patients for signs and symptoms of diabetes complications, such as neuropathy, retinopathy, nephropathy, cardiovascular disease, and foot problems.

When to Seek Help for Diabetes

Prompt medical attention is needed in certain situations:

  • Hypoglycemia: Especially severe hypoglycemia or recurrent episodes, or if hypoglycemia is not easily corrected with usual measures.
  • Hyperglycemia: Extreme hyperglycemia (very high blood glucose levels), particularly if accompanied by symptoms of DKA or HHS (e.g., nausea, vomiting, abdominal pain, rapid breathing, altered mental status).
  • Signs of Infection: Fever, chills, redness, swelling, pain, or purulent drainage, especially in wounds or feet.
  • Foot Problems: New foot ulcers, blisters, redness, swelling, pain, or changes in foot temperature.
  • Chest Pain, Shortness of Breath, or Symptoms of Stroke: Diabetes increases cardiovascular risk, and these symptoms require immediate evaluation.
  • Persistent Nausea, Vomiting, or Abdominal Pain: May indicate DKA or other serious conditions.
  • Changes in Vision: Sudden or worsening blurred vision, double vision, or vision loss.
  • Kidney Problems: Changes in urine output, swelling in legs or feet, or fatigue may indicate kidney disease.

Outcome Identification for Diabetes Management

Expected outcomes for patients with diabetes are individualized but generally include:

  • Glycemic Control: Achieving and maintaining target HbA1c levels as recommended by healthcare providers.
  • Prevention or Delay of Complications: Implementing strategies to minimize the risk of long-term complications.
  • Improved Quality of Life: Managing diabetes effectively to minimize symptoms and maintain functional abilities.
  • Self-Management Empowerment: Patients actively participating in their diabetes care, demonstrating knowledge and skills for self-management.
  • Adherence to Treatment Plan: Following prescribed medication regimens, dietary recommendations, and exercise plans.

Specific outcomes will vary depending on the patient’s individual circumstances, presence of complications, and overall health status.

Monitoring Diabetes Mellitus

Ongoing monitoring is crucial for effective diabetes management.

  • Regular HbA1c Testing: Typically every 3-6 months to assess long-term glycemic control.
  • Self-Monitoring of Blood Glucose (SMBG): Frequency and timing of SMBG are individualized based on treatment regimen and patient needs.
  • Annual Comprehensive Diabetes Exam: Includes assessment of glycemic control, blood pressure, lipid profile, kidney function, eye exam, foot exam, and neurological exam.
  • Ongoing Monitoring for Complications: Regularly assess for signs and symptoms of diabetes-related complications.

Coordination of Care for Diabetes

Optimal diabetes care requires a collaborative, interdisciplinary approach. Team members may include:

  • Primary Care Physician: Often the central coordinator of diabetes care.
  • Endocrinologist: Specialist in diabetes and hormone disorders, may be consulted for complex cases.
  • Diabetes Educator (CDE): Provides specialized education and support for diabetes self-management.
  • Registered Dietitian (RD): Provides medical nutrition therapy and individualized dietary plans.
  • Pharmacist: Provides medication management and education.
  • Nurses (RN, NP, LPN): Provide direct patient care, education, and coordination.
  • Ophthalmologist/Optometrist: For eye exams and management of diabetic retinopathy.
  • Podiatrist: For foot care and management of foot complications.
  • Cardiologist, Nephrologist, Neurologist: Consultants as needed for specific complications.
  • Mental Health Professionals: Address psychosocial issues and support mental well-being.
  • Social Worker/Case Manager: Address social and financial barriers to care, and assist with resource coordination.

Effective communication and collaboration among team members are essential to ensure patient-centered, comprehensive diabetes care.

Health Teaching and Health Promotion for Diabetes

Nurses play a vital role in health promotion and empowering patients to prevent or manage diabetes effectively. Key areas include:

  • Diabetes Prevention Education: Educate individuals at risk about lifestyle modifications to prevent T2DM, such as healthy eating, regular physical activity, and weight management.
  • Diabetes Self-Management Education (DSME): Provide comprehensive education to individuals with diabetes on all aspects of self-care, as outlined in the nursing management section.
  • Promoting Healthy Lifestyle Choices: Encourage healthy eating habits, regular physical activity, smoking cessation, and stress management for all individuals, especially those at risk for or diagnosed with diabetes.
  • Vaccination Promotion: Recommend annual influenza and pneumococcal vaccinations for people with diabetes, who are at increased risk for complications from these infections.
  • Regular Screening: Advocate for regular diabetes screening for at-risk individuals.

Risk Management in Diabetes Care

Patient safety is paramount. Risk management considerations include:

  • Hypoglycemia Prevention: Educate patients on hypoglycemia prevention, recognition, and treatment. Adjust medication regimens as needed to minimize hypoglycemia risk.
  • Medication Safety: Ensure accurate medication administration, especially for insulin. Provide clear instructions and address any patient barriers to safe medication use (e.g., vision impairment, cognitive limitations).
  • Foot Care Education and Prevention: Emphasize the importance of daily foot inspections and proper foot care to prevent foot ulcers and amputations.
  • Fall Prevention: Assess fall risk, especially in patients with neuropathy or vision changes, and implement fall prevention strategies.
  • Emergency Preparedness: Educate patients and families on how to respond to diabetes emergencies, such as severe hypoglycemia or hyperglycemia.

Discharge Planning for Patients with Diabetes

Effective discharge planning is crucial to ensure a smooth transition from hospital to home and continued diabetes management. Key elements include:

  • Medication Reconciliation and Education: Review all prescribed medications, dosages, administration instructions, and potential side effects. Ensure patients have prescriptions and understand how to obtain refills.
  • SMBG Plan: Review SMBG plan and ensure patients have necessary supplies and know how to perform SMBG at home.
  • Dietary and Exercise Recommendations: Reinforce dietary and exercise recommendations and provide resources for ongoing support.
  • Follow-up Appointments: Schedule follow-up appointments with primary care provider and specialists as needed (e.g., endocrinologist, ophthalmologist, podiatrist).
  • Referrals: Provide referrals to diabetes education programs, registered dietitians, and other support services as appropriate.
  • Emergency Contact Information: Ensure patients have contact information for their healthcare team and know when to seek urgent medical care.

Evidence-Based Issues in Diabetes Care

Numerous studies support the effectiveness of various interventions in diabetes management:

  • Lifestyle Modification Programs: Evidence strongly supports the benefits of structured lifestyle modification programs in improving glycemic control, weight management, and cardiovascular risk factors in T2DM.
  • Diabetes Self-Management Education (DSME): DSME has been shown to improve HbA1c levels, self-care behaviors, and quality of life in people with diabetes.
  • Interdisciplinary Care Teams: Collaborative care involving multiple healthcare professionals improves outcomes for patients with T2DM.
  • Pharmacological Therapies: Various medication classes have demonstrated efficacy in lowering blood glucose and reducing diabetes complications. Ongoing research continues to refine pharmacological approaches to diabetes management.

Nurses should stay current with evidence-based guidelines and incorporate best practices into their diabetes care.

Pearls and Other Important Considerations

  • Diabetes mellitus encompasses type 1, type 2, gestational, and drug-induced forms.
  • Risk factors for T2DM are multifactorial, including genetics, ethnicity, age, obesity, and lifestyle.
  • HbA1c is a key diagnostic and monitoring test for diabetes.
  • Medical management of T2DM typically involves lifestyle modification and pharmacotherapy, often starting with metformin.
  • Lifestyle modification is crucial for blood glucose control and overall health.
  • Patients should consult their healthcare provider to determine appropriate SMBG frequency.
  • Carbohydrate intake, not just sugar, significantly impacts blood glucose levels.
  • Patient education is a cornerstone of effective diabetes management.

Review Questions

(Note: Review questions are omitted as per the user’s request to focus on content transformation)

References

(Note: References from the original article are retained)

  1. Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018 Feb;14(2):88-98. [PubMed: 29219149]
  2. Malek R, Hannat S, Nechadi A, Mekideche FZ, Kaabeche M. Diabetes and Ramadan: A multicenter study in Algerian population. Diabetes Res Clin Pract. 2019 Apr;150:322-330. [PubMed: 30779972]
  3. Choi YJ, Chung YS. Type 2 diabetes mellitus and bone fragility: Special focus on bone imaging. Osteoporos Sarcopenia. 2016 Mar;2(1):20-24. [PMC free article: PMC6372751] [PubMed: 30775463]
  4. Picke AK, Campbell G, Napoli N, Hofbauer LC, Rauner M. Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties. Endocr Connect. 2019 Mar 01;8(3):R55-R70. [PMC free article: PMC6391903] [PubMed: 30772871]
  5. Carrillo-Larco RM, Barengo NC, Albitres-Flores L, Bernabe-Ortiz A. The risk of mortality among people with type 2 diabetes in Latin America: A systematic review and meta-analysis of population-based cohort studies. Diabetes Metab Res Rev. 2019 May;35(4):e3139. [PubMed: 30761721]
  6. Hussain S, Chowdhury TA. The Impact of Comorbidities on the Pharmacological Management of Type 2 Diabetes Mellitus. Drugs. 2019 Feb;79(3):231-242. [PubMed: 30742277]
  7. Kempegowda P, Chandan JS, Abdulrahman S, Chauhan A, Saeed MA. Managing hypertension in people of African origin with diabetes: Evaluation of adherence to NICE Guidelines. Prim Care Diabetes. 2019 Jun;13(3):266-271. [PubMed: 30704854]
  8. Martinez LC, Sherling D, Holley A. The Screening and Prevention of Diabetes Mellitus. Prim Care. 2019 Mar;46(1):41-52. [PubMed: 30704659]
  9. Thewjitcharoen Y, Chotwanvirat P, Jantawan A, Siwasaranond N, Saetung S, Nimitphong H, Himathongkam T, Reutrakul S. Evaluation of Dietary Intakes and Nutritional Knowledge in Thai Patients with Type 2 Diabetes Mellitus. J Diabetes Res. 2018;2018:9152910. [PMC free article: PMC6317123] [PubMed: 30671482]
  10. Willis M, Asseburg C, Neslusan C. Conducting and interpreting results of network meta-analyses in type 2 diabetes mellitus: A review of network meta-analyses that include sodium glucose co-transporter 2 inhibitors. Diabetes Res Clin Pract. 2019 Feb;148:222-233. [PubMed: 30641163]
  11. Lai LL, Wan Yusoff WNI, Vethakkan SR, Nik Mustapha NR, Mahadeva S, Chan WK. Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography. J Gastroenterol Hepatol. 2019 Aug;34(8):1396-1403. [PubMed: 30551263]
  12. Eckstein ML, Williams DM, O’Neil LK, Hayes J, Stephens JW, Bracken RM. Physical exercise and non-insulin glucose-lowering therapies in the management of Type 2 diabetes mellitus: a clinical review. Diabet Med. 2019 Mar;36(3):349-358. [PubMed: 30536728]
  13. Massey CN, Feig EH, Duque-Serrano L, Wexler D, Moskowitz JT, Huffman JC. Well-being interventions for individuals with diabetes: A systematic review. Diabetes Res Clin Pract. 2019 Jan;147:118-133. [PMC free article: PMC6370485] [PubMed: 30500545]
  14. Shah SR, Iqbal SM, Alweis R, Roark S. A closer look at heart failure in patients with concurrent diabetes mellitus using glucose lowering drugs. Expert Rev Clin Pharmacol. 2019 Jan;12(1):45-52. [PubMed: 30488734]
  15. Chinese Diabetes Society; National Offic for Primary Diabetes Care. [National guidelines for the prevention and control of diabetes in primary care(2018)]. Zhonghua Nei Ke Za Zhi. 2018 Dec 01;57(12):885-893. [PubMed: 30486556]
  16. Petersmann A, Müller-Wieland D, Müller UA, Landgraf R, Nauck M, Freckmann G, Heinemann L, Schleicher E. Definition, Classification and Diagnosis of Diabetes Mellitus. Exp Clin Endocrinol Diabetes. 2019 Dec;127(S 01):S1-S7. [PubMed: 31860923]
  17. Kerner W, Brückel J., German Diabetes Association. Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes. 2014 Jul;122(7):384-6. [PubMed: 25014088]
  18. Cepeda Marte JL, Ruiz-Matuk C, Mota M, Pérez S, Recio N, Hernández D, Fernández J, Porto J, Ramos A. Quality of life and metabolic control in type 2 diabetes mellitus diagnosed individuals. Diabetes Metab Syndr. 2019 Sep-Oct;13(5):2827-2832. [PubMed: 31425943]
  19. Steffensen C, Dekkers OM, Lyhne J, Pedersen BG, Rasmussen F, Rungby J, Poulsen PL, Jørgensen JOL. Hypercortisolism in Newly Diagnosed Type 2 Diabetes: A Prospective Study of 384 Newly Diagnosed Patients. Horm Metab Res. 2019 Jan;51(1):62-68. [PubMed: 30522146]
  20. Qin Z, Zhou K, Li Y, Cheng W, Wang Z, Wang J, Gao F, Yang L, Xu Y, Wu Y, He H, Zhou Y. The atherogenic index of plasma plays an important role in predicting the prognosis of type 2 diabetic subjects undergoing percutaneous coronary intervention: results from an observational cohort study in China. Cardiovasc Diabetol. 2020 Feb 21;19(1):23. [PMC free article: PMC7035714] [PubMed: 32085772]
  21. Nowakowska M, Zghebi SS, Ashcroft DM, Buchan I, Chew-Graham C, Holt T, Mallen C, Van Marwijk H, Peek N, Perera-Salazar R, Reeves D, Rutter MK, Weng SF, Qureshi N, Mamas MA, Kontopantelis E. Correction to: The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Med. 2020 Jan 25;18(1):22. [PMC free article: PMC6982380] [PubMed: 31980024]
  22. Akalu Y, Birhan A. Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia. J Diabetes Res. 2020;2020:9419413. [PMC free article: PMC7008281] [PubMed: 32090126]
  23. Patoulias D, Papadopoulos C, Stavropoulos K, Zografou I, Doumas M, Karagiannis A. Prognostic value of arterial stiffness measurements in cardiovascular disease, diabetes, and its complications: The potential role of sodium-glucose co-transporter-2 inhibitors. J Clin Hypertens (Greenwich). 2020 Apr;22(4):562-571. [PMC free article: PMC8029715] [PubMed: 32058679]
  24. Liakopoulos V, Franzén S, Svensson AM, Miftaraj M, Ottosson J, Näslund I, Gudbjörnsdottir S, Eliasson B. Pros and cons of gastric bypass surgery in individuals with obesity and type 2 diabetes: nationwide, matched, observational cohort study. BMJ Open. 2019 Jan 15;9(1):e023882. [PMC free article: PMC6340417] [PubMed: 30782717]
  25. Su YJ, Chen TH, Hsu CY, Chiu WT, Lin YS, Chi CC. Safety of Metformin in Psoriasis Patients With Diabetes Mellitus: A 17-Year Population-Based Real-World Cohort Study. J Clin Endocrinol Metab. 2019 Aug 01;104(8):3279-3286. [PubMed: 30779846]
  26. Choi SE, Berkowitz SA, Yudkin JS, Naci H, Basu S. Personalizing Second-Line Type 2 Diabetes Treatment Selection: Combining Network Meta-analysis, Individualized Risk, and Patient Preferences for Unified Decision Support. Med Decis Making. 2019 Apr;39(3):239-252. [PMC free article: PMC6469997] [PubMed: 30767632]

Comments

No comments yet. Why don’t you start the discussion?

Leave a Reply

Your email address will not be published. Required fields are marked *