Antisocial Personality Disorder (ASPD) is a complex psychiatric condition characterized by a persistent disregard for the rights and feelings of others. While often used interchangeably in popular culture, psychopathy and ASPD are related but distinct concepts within the realm of personality disorders. Understanding the nuances of “Psychopath Diagnosis Criteria,” particularly as they intersect with ASPD, is crucial for clinicians in accurate assessment, differential diagnosis, and effective management strategies. This article provides an in-depth exploration of these criteria, drawing upon established diagnostic frameworks and assessment tools to guide healthcare professionals.
Understanding Antisocial Personality Disorder (ASPD)
Antisocial Personality Disorder, as defined in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM-5-TR), is marked by a pervasive pattern of disregard for and violation of the rights of others that begins in childhood or early adolescence and continues into adulthood. Individuals with ASPD often exhibit manipulative behaviors, a lack of empathy, and minimal remorse for their actions. This pattern significantly impairs their interpersonal relationships, occupational functioning, and overall societal integration. Legal issues are common due to their repeated failure to learn from negative consequences and a propensity for criminal behavior.[1]
Image alt text: Visual representation illustrating the correlation between adult antisocial personality traits and experiences of inadequate parental care combined with excessive maternal overprotection during childhood.
ASPD Diagnostic Criteria (DSM-5-TR)
The DSM-5-TR provides specific criteria for diagnosing ASPD. A diagnosis requires meeting the following conditions:
-
A pervasive pattern of disregard for and violation of the rights of others, occurring since age 15 years, as indicated by three (or more) of the following:
a. Failure to conform to social norms with respect to lawful behaviors, as indicated by repeatedly performing acts that are grounds for arrest.
b. Deceitfulness, as indicated by repeated lying, use of aliases, or conning others for personal profit or pleasure.
c. Impulsivity or failure to plan ahead.
d. Irritability and aggressiveness, as indicated by repeated physical fights or assaults.
e. Reckless disregard for safety of self or others.
f. Consistent irresponsibility, as indicated by repeated failure to sustain steady work behavior or honor financial obligations.
g. Lack of remorse, as indicated by being indifferent to or rationalizing having hurt, mistreated, or stolen from another. -
The individual is at least age 18 years.
-
There is evidence of conduct disorder with onset before age 15 years.
-
The occurrence of antisocial behavior is not exclusively during the course of schizophrenia or bipolar disorder.
Each of these criteria points to a distinct facet of the antisocial personality construct. For instance, “failure to conform to social norms” encompasses a broad range of law-breaking behaviors, from petty theft to more serious crimes. “Deceitfulness” highlights the manipulative nature often seen in ASPD, while “lack of remorse” underscores the emotional deficits central to the disorder. The requirement of conduct disorder before age 15 is crucial, emphasizing the developmental origins of ASPD.
Psychopathy and its Relationship to ASPD
While ASPD is a formal diagnosis in the DSM-5-TR, “psychopathy” is not. However, psychopathy is a closely related construct, often considered a more severe and specific manifestation of antisocial traits. It is characterized by a distinct cluster of personality traits and behaviors that go beyond the DSM-5-TR criteria for ASPD. Psychopathy is often associated with a heightened risk of violence and a more callous and unemotional interpersonal style.[6]
Robert Hare, a prominent researcher in psychopathy, developed the Psychopathy Checklist-Revised (PCL-R), a widely used assessment tool for measuring psychopathic traits. The PCL-R provides a more nuanced understanding of psychopathy, differentiating it from the broader category of ASPD. [7] It’s important to note that while not every individual with ASPD is a psychopath, psychopathy is often considered a subtype within the spectrum of ASPD.
Image alt text: Graphical representation of findings from twin studies, illustrating a 67% concordance rate for monozygotic twins compared to a 31% rate for dizygotic twins in the context of antisocial personality traits.
Psychopathy Checklist-Revised (PCL-R) and Psychopath Diagnosis Criteria
The PCL-R is a semi-structured interview and file review instrument used to assess psychopathic personality traits. It consists of 20 items scored on a 3-point scale (0, 1, or 2), resulting in a total score that indicates the degree of psychopathy. The items are categorized into two main factors and four facets:
Factor 1: Interpersonal/Affective
-
Facet 1A: Interpersonal:
- Glibness/Superficial Charm
- Grandiose Sense of Self-Worth
- Pathological Lying
- Conning/Manipulative
-
Facet 1B: Affective:
- Lack of Remorse or Guilt
- Shallow Affect
- Callous/Lack of Empathy
- Failure to Accept Responsibility
Factor 2: Lifestyle/Antisocial
-
Facet 2A: Lifestyle:
- Need for Stimulation/Proneness to Boredom
- Parasitic Lifestyle
- Lack of Realistic, Long-Term Goals
- Impulsivity
- Irresponsibility
-
Facet 2B: Antisocial:
- Poor Behavioral Controls
- Early Behavior Problems
- Juvenile Delinquency
- Revocation of Conditional Release
- Criminal Versatility
Items Not Factored:
- Promiscuous Sexual Behavior
- Many Short-Term Marital Relationships
The PCL-R provides a score that helps clinicians assess the presence and severity of psychopathic traits. While there is no official “psychopath diagnosis” in DSM-5-TR, a high score on the PCL-R (typically above 30 in North American samples) is often used to identify individuals with psychopathy. It’s crucial to remember that the PCL-R is an assessment tool, not a diagnostic label itself. It informs clinical judgment, risk assessment, and treatment planning, especially within forensic and correctional settings.
Differentiating ASPD and Psychopathy from Other Disorders
Accurate diagnosis requires differentiating ASPD and psychopathy from other mental health conditions that may share overlapping symptoms.
- Borderline Personality Disorder (BPD): While both ASPD and BPD fall within Cluster B personality disorders, BPD is characterized by emotional instability, identity disturbance, and fear of abandonment, which are not core features of psychopathy or ASPD. Individuals with BPD often exhibit inward distress and self-harming behaviors, contrasting with the outward aggression and lack of remorse in ASPD and psychopathy.[89]
- Narcissistic Personality Disorder (NPD): NPD shares traits like grandiosity and a lack of empathy with psychopathy, but individuals with NPD are typically less prone to aggression and criminal behavior. The primary motivation in NPD is often admiration and validation, whereas in psychopathy, it is often exploitation and control.[90]
- Substance Use Disorders: Substance abuse can induce antisocial behaviors, but ASPD and psychopathy are enduring personality patterns that persist regardless of substance use. It’s essential to distinguish between substance-induced antisocial behavior and ingrained antisocial personality traits.
- Intermittent Explosive Disorder: This disorder involves discrete episodes of aggression, unlike the pervasive pattern of antisocial behavior in ASPD. Intermittent explosive disorder also lacks the history of conduct disorder and broader social and occupational impairments seen in ASPD.[88]
A thorough clinical history, including childhood behavior, interpersonal patterns, and emotional functioning, is crucial for accurate differential diagnosis.
Etiology of ASPD and Psychopathic Traits
The development of ASPD and psychopathic traits is multifactorial, involving a complex interplay of genetic, neurobiological, and environmental factors.
- Genetics: Twin and family studies suggest a significant heritable component to ASPD and related traits. Genetic factors may influence temperament, impulsivity, and emotional processing, predisposing individuals to antisocial behaviors.[23]
- Neurodevelopment: Research indicates structural and functional brain differences in individuals with ASPD and psychopathy, particularly in prefrontal cortex, amygdala, and anterior cingulate cortex regions involved in emotional regulation, decision-making, and empathy. Underarousal of the autonomic nervous system has also been proposed as a contributing factor.[51]
- Psychosocial Factors: Adverse childhood experiences, such as abuse, neglect, and inconsistent parenting, are significant risk factors for ASPD and the development of psychopathic traits. These experiences can disrupt healthy personality development and contribute to maladaptive coping mechanisms and interpersonal patterns.[37]
It’s important to recognize that etiology is complex and not deterministic. Individuals with genetic predispositions or adverse childhoods do not inevitably develop ASPD or psychopathy, highlighting the interplay of multiple risk and protective factors.
Assessment and Evaluation for ASPD and Psychopathic Traits
A comprehensive assessment for ASPD and psychopathic traits involves multiple methods:
- Clinical Interview: A detailed clinical interview is essential to gather information about the individual’s history, behavior patterns, interpersonal relationships, and emotional functioning. Collateral information from family members or other sources can be valuable, as individuals with ASPD may be unreliable historians.[59]
- Mental Status Examination: While the mental status exam may not reveal specific diagnostic features of ASPD, it can assess for impulsivity, judgment, insight, and affect, providing clues to personality functioning.[61]
- Psychological Testing:
- MMPI (Minnesota Multiphasic Personality Inventory): The MMPI can identify personality patterns associated with ASPD, such as psychopathic deviance scales.[69]
- PPI (Psychopathic Personality Inventory): The PPI is specifically designed to assess psychopathic personality traits in non-forensic populations.[70]
- PCL-R (Psychopathy Checklist-Revised): As discussed, the PCL-R is the gold standard for assessing psychopathic traits, particularly in forensic and correctional settings.
The diagnosis of ASPD relies primarily on DSM-5-TR criteria, while the assessment of psychopathic traits utilizes tools like the PCL-R to provide a more in-depth understanding of an individual’s personality profile and risk factors.
Treatment and Management Considerations
ASPD and psychopathy are notoriously challenging to treat. Individuals with these conditions often lack motivation for change and may not perceive their behaviors as problematic.
- Psychotherapy: Various psychotherapeutic approaches have been attempted, including:
- Transference-Focused Psychotherapy (TFP): TFP may be beneficial in addressing underlying personality structures and improving interpersonal functioning.[81]
- Cognitive Behavioral Therapy (CBT): CBT strategies can focus on modifying maladaptive beliefs and behaviors, improving social skills, and enhancing problem-solving abilities.
- Pharmacotherapy: There are no FDA-approved medications specifically for ASPD. Medications may be used to target comorbid conditions like anxiety, depression, or aggression. Second-generation antipsychotics or SSRIs may be considered for managing impulsivity or aggression, but their effectiveness is limited and inconsistent.[74]
Management strategies often focus on harm reduction, risk management, and improving psychosocial functioning rather than aiming for a complete “cure.” Case management, structured environments, and interventions that address comorbid substance use disorders are often essential components of care.
Conclusion
Understanding “psychopath diagnosis criteria” and their relationship to ASPD is vital for clinicians working with individuals exhibiting antisocial behaviors. While DSM-5-TR provides the diagnostic framework for ASPD, tools like the PCL-R offer a more detailed assessment of psychopathic traits, informing risk assessment and management strategies. Accurate diagnosis, differential diagnosis, and a comprehensive understanding of etiological factors are crucial for developing effective, albeit often challenging, management plans. A multidisciplinary approach, focusing on harm reduction, managing comorbidities, and improving psychosocial functioning, is often the most realistic and helpful strategy for individuals with ASPD and psychopathic traits. Continued research is needed to refine diagnostic approaches and develop more effective treatment interventions for these complex and challenging conditions.
References
1.Clark DA, Donnellan MB, Robins RW. Antisocial Traits, Negative Emotionality, and Trajectories of Relationship Quality in Mexican-Origin Couples. J Pers Disord. 2020 Aug;34(4):459-479. [PubMed: 31403390]
2.Mohan L, Yilanli M, Ray S. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Jul 10, 2023. Conduct Disorder. [PubMed: 29261891]
3.Junewicz A, Billick SB. Conduct Disorder: Biology and Developmental Trajectories. Psychiatr Q. 2020 Mar;91(1):77-90. [PubMed: 31768912]
4.Gelhorn HL, Sakai JT, Price RK, Crowley TJ. DSM-IV conduct disorder criteria as predictors of antisocial personality disorder. Compr Psychiatry. 2007 Nov-Dec;48(6):529-38. [PMC free article: PMC2764329] [PubMed: 17954138]
5.Sagar R, Patra BN, Patil V. Clinical Practice Guidelines for the management of conduct disorder. Indian J Psychiatry. 2019 Jan;61(Suppl 2):270-276. [PMC free article: PMC6345126] [PubMed: 30745702]
6.Coid J, Ullrich S. Antisocial personality disorder is on a continuum with psychopathy. Compr Psychiatry. 2010 Jul-Aug;51(4):426-33. [PubMed: 20579518]
7.Hare RD, Neumann CS. Psychopathy as a clinical and empirical construct. Annu Rev Clin Psychol. 2008;4:217-46. [PubMed: 18370617]
8.Charland LC. Science and morals in the affective psychopathology of Philippe Pinel. Hist Psychiatry. 2010 Mar;21(81 Pt 1):38-53. [PubMed: 21877429]
9.Kendler KS. Philippe Pinel and the foundations of modern psychiatric nosology. Psychol Med. 2020 Dec;50(16):2667-2672. [PubMed: 33213600]
10.Crego C, Widiger TA. Cleckley’s psychopaths: Revisited. J Abnorm Psychol. 2016 Jan;125(1):75-87. [PubMed: 26618655]
11.Lilienfeld SO, Watts AL, Smith SF, Patrick CJ, Hare RD. Hervey Cleckley (1903-1984): Contributions to the study of psychopathy. Personal Disord. 2018 Nov;9(6):510-520. [PubMed: 30080062]
12.First MB, Yousif LH, Clarke DE, Wang PS, Gogtay N, Appelbaum PS. DSM-5-TR: overview of what’s new and what’s changed. World Psychiatry. 2022 Jun;21(2):218-219. [PMC free article: PMC9077590] [PubMed: 35524596]
13.Hopwood CJ, Thomas KM, Markon KE, Wright AG, Krueger RF. DSM-5 personality traits and DSM-IV personality disorders. J Abnorm Psychol. 2012 May;121(2):424-32. [PMC free article: PMC3909514] [PubMed: 22250660]
14.Tackett JL, Silberschmidt AL, Krueger RF, Sponheim SR. A dimensional model of personality disorder: incorporating DSM Cluster A characteristics. J Abnorm Psychol. 2008 May;117(2):454-9. [PubMed: 18489222]
15.DeLisi M, Drury AJ, Elbert MJ. The etiology of antisocial personality disorder: The differential roles of adverse childhood experiences and childhood psychopathology. Compr Psychiatry. 2019 Jul;92:1-6. [PubMed: 31079021]
16.Sanchez-Roige S, Gray JC, MacKillop J, Chen CH, Palmer AA. The genetics of human personality. Genes Brain Behav. 2018 Mar;17(3):e12439. [PMC free article: PMC7012279] [PubMed: 29152902]
17.Réale D, Reader SM, Sol D, McDougall PT, Dingemanse NJ. Integrating animal temperament within ecology and evolution. Biol Rev Camb Philos Soc. 2007 May;82(2):291-318. [PubMed: 17437562]
18.Svrakic DM, Cloninger RC. Epigenetic perspective on behavior development, personality, and personality disorders. Psychiatr Danub. 2010 Jun;22(2):153-66. [PubMed: 20562740]
19.Gescher DM, Kahl KG, Hillemacher T, Frieling H, Kuhn J, Frodl T. Epigenetics in Personality Disorders: Today’s Insights. Front Psychiatry. 2018;9:579. [PMC free article: PMC6252387] [PubMed: 30510522]
20.Wan L, Zha R, Ren J, Li Y, Zhao Q, Zuo H, Zhang X. Brain morphology, harm avoidance, and the severity of excessive internet use. Hum Brain Mapp. 2022 Jul;43(10):3176-3183. [PMC free article: PMC9188967] [PubMed: 35332975]
21.Gocłowska MA, Ritter SM, Elliot AJ, Baas M. Novelty seeking is linked to openness and extraversion, and can lead to greater creative performance. J Pers. 2019 Apr;87(2):252-266. [PubMed: 29604214]
22.Frank GKW, Shott ME, Sternheim LC, Swindle S, Pryor TL. Persistence, Reward Dependence, and Sensitivity to Reward Are Associated With Unexpected Salience Response in Girls but Not in Adult Women: Implications for Psychiatric Vulnerabilities. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Nov;7(11):1170-1182. [PubMed: 33872764]
23.Brennan PA, Mednick SA. Genetic perspectives on crime. Acta Psychiatr Scand Suppl. 1993;370:19-26. [PubMed: 8452051]
24.Guze SB, Wolfgram ED, McKinney JK, Cantwell DP. Psychiatric illness in the families of convicted criminals: a study of 519 first-degree relatives. Dis Nerv Syst. 1967 Oct;28(10):651-9. [PubMed: 6051292]
25.Krueger RF, Hicks BM, Patrick CJ, Carlson SR, Iacono WG, McGue M. Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum. J Abnorm Psychol. 2002 Aug;111(3):411-24. [PubMed: 12150417]
26.Rosenström T, Ystrom E, Torvik FA, Czajkowski NO, Gillespie NA, Aggen SH, Krueger RF, Kendler KS, Reichborn-Kjennerud T. Genetic and Environmental Structure of DSM-IV Criteria for Antisocial Personality Disorder: A Twin Study. Behav Genet. 2017 May;47(3):265-277. [PMC free article: PMC5404958] [PubMed: 28108863]
27.Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. Role of genotype in the cycle of violence in maltreated children. Science. 2002 Aug 02;297(5582):851-4. [PubMed: 12161658]
28.Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry. 1994 Jan;51(1):34-8. [PubMed: 7506517]
29.da Cunha-Bang S, Knudsen GM. The Modulatory Role of Serotonin on Human Impulsive Aggression. Biol Psychiatry. 2021 Oct 01;90(7):447-457. [PubMed: 34266672]
30.Scarpa A, Raine A. Psychophysiology of anger and violent behavior. Psychiatr Clin North Am. 1997 Jun;20(2):375-94. [PubMed: 9196920]
31.Leppla I, Fishman D, Kalra I, Oldham MA. Clinical Approach to Personality Change Due to Another Medical Condition. J Acad Consult Liaison Psychiatry. 2021 Jan-Feb;62(1):14-21. [PubMed: 33190792]
32.Neugebauer R, Hoek HW, Susser E. Prenatal exposure to wartime famine and development of antisocial personality disorder in early adulthood. JAMA. 1999 Aug 04;282(5):455-62. [PubMed: 10442661]
33.Wakschlag LS, Lahey BB, Loeber R, Green SM, Gordon RA, Leventhal BL. Maternal smoking during pregnancy and the risk of conduct disorder in boys. Arch Gen Psychiatry. 1997 Jul;54(7):670-6. [PubMed: 9236551]
34.Newlin E, Weinstein B. Personality disorders. Continuum (Minneap Minn). 2015 Jun;21(3 Behavioral Neurology and Neuropsychiatry):806-17. [PubMed: 26039856]
35.Shapiro D. Theoretical reflections on Wilhelm Reich’s Character Analysis. Am J Psychother. 2002;56(3):338-46. [PubMed: 12400201]
36.Di Giuseppe M, Perry JC. The Hierarchy of Defense Mechanisms: Assessing Defensive Functioning With the Defense Mechanisms Rating Scales Q-Sort. Front Psychol. 2021;12:718440. [PMC free article: PMC8555762] [PubMed: 34721167]
37.Reti IM, Samuels JF, Eaton WW, Bienvenu OJ, Costa PT, Nestadt G. Adult antisocial personality traits are associated with experiences of low parental care and maternal overprotection. Acta Psychiatr Scand. 2002 Aug;106(2):126-33. [PubMed: 12121210]
38.Luntz BK, Widom CS. Antisocial personality disorder in abused and neglected children grown up. Am J Psychiatry. 1994 May;151(5):670-4. [PubMed: 8166307]
39.Egami Y, Ford DE, Greenfield SF, Crum RM. Psychiatric profile and sociodemographic characteristics of adults who report physically abusing or neglecting children. Am J Psychiatry. 1996 Jul;153(7):921-8. [PubMed: 8659615]
40.Brewer AJ, Saunders R, Fearon P, Fonagy P, Cottrell D, Kraam A, Pilling S, Simes E, Anokhina A, Butler S. Antisocial cognition as a mediator of the peer influence effect and peer selection effect in antisocial adolescents. Eur Child Adolesc Psychiatry. 2022 Jan;31(1):177-187. [PMC free article: PMC8816781] [PubMed: 33330952]
41.Monahan KC, Steinberg L, Cauffman E. Affiliation with antisocial peers, susceptibility to peer influence, and antisocial behavior during the transition to adulthood. Dev Psychol. 2009 Nov;45(6):1520-30. [PMC free article: PMC2886974] [PubMed: 19899911]
42.Shao R, Wang Y. The Relation of Violent Video Games to Adolescent Aggression: An Examination of Moderated Mediation Effect. Front Psychol. 2019;10:384. [PMC free article: PMC6394371] [PubMed: 30846962]
43.Wiegman O, van Schie EG. Video game playing and its relations with aggressive and prosocial behaviour. Br J Soc Psychol. 1998 Sep;37 ( Pt 3):367-78. [PubMed: 9738313]
44.Chen MJ, Miller BA, Grube JW, Waiters ED. Music, substance use, and aggression. J Stud Alcohol. 2006 May;67(3):373-81. [PMC free article: PMC5066304] [PubMed: 16608146]
45.Moran P. The epidemiology of antisocial personality disorder. Soc Psychiatry Psychiatr Epidemiol. 1999 May;34(5):231-42. [PubMed: 10396164]
46.Black DW, Gunter T, Loveless P, Allen J, Sieleni B. Antisocial personality disorder in incarcerated offenders: Psychiatric comorbidity and quality of life. Ann Clin Psychiatry. 2010 May;22(2):113-20. [PubMed: 20445838]
47.Grant BF, Hasin DS, Stinson FS, Dawson DA, Chou SP, Ruan WJ, Pickering RP. Prevalence, correlates, and disability of personality disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry. 2004 Jul;65(7):948-58. [PubMed: 15291684]
48.Compton WM, Conway KP, Stinson FS, Colliver JD, Grant BF. Prevalence, correlates, and comorbidity of DSM-IV antisocial personality syndromes and alcohol and specific drug use disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry. 2005 Jun;66(6):677-85. [PubMed: 15960559]
49.Neumann CS, Hare RD. Psychopathic traits in a large community sample: links to violence, alcohol use, and intelligence. J Consult Clin Psychol. 2008 Oct;76(5):893-9. [PubMed: 18837606]
50.Simonoff E, Elander J, Holmshaw J, Pickles A, Murray R, Rutter M. Predictors of antisocial personality. Continuities from childhood to adult life. Br J Psychiatry. 2004 Feb;184:118-27. [PubMed: 14754823]
51.Raine A. Autonomic nervous system factors underlying disinhibited, antisocial, and violent behavior. Biosocial perspectives and treatment implications. Ann N Y Acad Sci. 1996 Sep 20;794:46-59. [PubMed: 8853591]
52.Dolan M. Psychopathy–a neurobiological perspective. Br J Psychiatry. 1994 Aug;165(2):151-9. [PubMed: 7953028]
53.Raine A, Venables PH, Williams M. Relationships between central and autonomic measures of arousal at age 15 years and criminality at age 24 years. Arch Gen Psychiatry. 1990 Nov;47(11):1003-7. [PubMed: 2241502]
54.Moffitt TE, Lynam D. The neuropsychology of conduct disorder and delinquency: implications for understanding antisocial behavior. Prog Exp Pers Psychopathol Res. 1994:233-62. [PubMed: 8044205]
55.Dolan MC. What imaging tells us about violence in anti-social men. Crim Behav Ment Health. 2010 Jul;20(3):199-214. [PubMed: 20549783]
56.Goyer PF, Andreason PJ, Semple WE, Clayton AH, King AC, Compton-Toth BA, Schulz SC, Cohen RM. Positron-emission tomography and personality disorders. Neuropsychopharmacology. 1994 Feb;10(1):21-8. [PubMed: 8179791]
57.Raine A, Lencz T, Bihrle S, LaCasse L, Colletti P. Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Arch Gen Psychiatry. 2000 Feb;57(2):119-27; discussion 128-9. [PubMed: 10665614]
58.Robins LN, Price RK. Adult disorders predicted by childhood conduct problems: results from the NIMH Epidemiologic Catchment Area project. Psychiatry. 1991 May;54(2):116-32. [PubMed: 1852846]
59.Andreasen NC, Rice J, Endicott J, Reich T, Coryell W. The family history approach to diagnosis. How useful is it? Arch Gen Psychiatry. 1986 May;43(5):421-9. [PubMed: 3964020]
60.Black DW, Baumgard CH, Bell SE. The long-term outcome of antisocial personality disorder compared with depression, schizophrenia, and surgical conditions. Bull Am Acad Psychiatry Law. 1995;23(1):43-52. [PubMed: 7599370]
61.Dinwiddie SH, Cottler L, Compton W, Abdallah AB. Psychopathology and HIV risk behaviors among injection drug users in and out of treatment. Drug Alcohol Depend. 1996 Dec 02;43(1-2):1-11. [PubMed: 8957138]
62.Goldstein RB, Dawson DA, Chou SP, Ruan WJ, Saha TD, Pickering RP, Stinson FS, Grant BF. Antisocial behavioral syndromes and past-year physical health among adults in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2008 Mar;69(3):368-80. [PMC free article: PMC2958062] [PubMed: 18348594]
63.Ellis D, Collis I, King M. Personality disorder and sexual risk taking among homosexually active and heterosexually active men attending a genito-urinary medicine clinic. J Psychosom Res. 1995 Oct;39(7):901-10. [PubMed: 8636922]
64.Henry BF. Treating Gang-Involved Patients: Embodied Trauma & How to Heal from Life on the Street. Prof Dev (Phila). 2019 Fall;22(2):3-10. [PMC free article: PMC7310987] [PubMed: 32577076]
65.Raspa RF, Cusack J. Psychiatric implications of tattoos. Am Fam Physician. 1990 May;41(5):1481-6. [PubMed: 2333825]
66.Clark LA. Assessment and diagnosis of personality disorder: perennial issues and an emerging reconceptualization. Annu Rev Psychol. 2007;58:227-57. [PubMed: 16903806]
67.Campbell K, Clarke KA, Massey D, Lakeman R. Borderline Personality Disorder: To diagnose or not to diagnose? That is the question. Int J Ment Health Nurs. 2020 Oct;29(5):972-981. [PubMed: 32426937]
68.Dao TK, Prevatt F, Horne HL. Differentiating psychotic patients from nonpsychotic patients with the MMPI-2 and Rorschach. J Pers Assess. 2008 Jan;90(1):93-101. [PubMed: 18444100]
69.Sellbom M, Ben-Porath YS, Lilienfeld SO, Patrick CJ, Graham JR. Assessing psychopathic personality traits with the MMPI-2. J Pers Assess. 2005 Dec;85(3):334-43. [PubMed: 16318573]
70.Falkenbach DM, Reinhard EE, Zappala M. Identifying Psychopathy Subtypes Using a Broader Model of Personality: An Investigation of the Five Factor Model Using Model-Based Cluster Analysis. J Interpers Violence. 2021 Aug;36(15-16):7161-7184. [PubMed: 30827139]
71.Frick PJ. Early Identification and Treatment of Antisocial Behavior. Pediatr Clin North Am. 2016 Oct;63(5):861-71. [PubMed: 27565364]
72.Weinberg I, Ronningstam E. Dos and Don’ts in Treatments of Patients With Narcissistic Personality Disorder. J Pers Disord. 2020 Mar;34(Suppl):122-142. [PubMed: 32186986]
73.Bateman A, O’Connell J, Lorenzini N, Gardner T, Fonagy P. A randomised controlled trial of mentalization-based treatment versus structured clinical management for patients with comorbid borderline personality disorder and antisocial personality disorder. BMC Psychiatry. 2016 Aug 30;16(1):304. [PMC free article: PMC5006360] [PubMed: 27577562]
74.Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry. 1997 Dec;54(12):1081-8. [PubMed: 9400343]
75.Müller-Oerlinghausen B, Lewitzka U. Lithium reduces pathological aggression and suicidality: a mini-review. Neuropsychobiology. 2010;62(1):43-9. [PubMed: 20453534]
76.Barratt ES, Stanford MS, Felthous AR, Kent TA. The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol. 1997 Oct;17(5):341-9. [PubMed: 9315984]
77.Huband N, Ferriter M, Nathan R, Jones H. Antiepileptics for aggression and associated impulsivity. Cochrane Database Syst Rev. 2010 Feb 17;2010(2):CD003499. [PMC free article: PMC4163499] [PubMed: 20166067]
78.Stanford MS, Helfritz LE, Conklin SM, Villemarette-Pittman NR, Greve KW, Adams D, Houston RJ. A comparison of anticonvulsants in the treatment of impulsive aggression. Exp Clin Psychopharmacol. 2005 Feb;13(1):72-7. [PubMed: 15727506]
79.Corrigan PW, Yudofsky SC, Silver JM. Pharmacological and behavioral treatments for aggressive psychiatric inpatients. Hosp Community Psychiatry. 1993 Feb;44(2):125-33. [PubMed: 8432495]
80.Cowdry RW, Gardner DL. Pharmacotherapy of borderline personality disorder. Alprazolam, carbamazepine, trifluoperazine, and tranylcypromine. Arch Gen Psychiatry. 1988 Feb;45(2):111-9. [PubMed: 3276280]
81.Diamond D, Yeomans F, Keefe JR. Transference-Focused Psychotherapy for Pathological Narcissism and Narcissistic Personality Disorder (TFP-N). Psychodyn Psychiatry. 2021 Summer;49(2):244-272. [PubMed: 34061655]
82.Kernberg OF. An overview of the treatment of severe narcissistic pathology. Int J Psychoanal. 2014 Oct;95(5):865-88. [PubMed: 24902768]
83.Ritter S, Platt LM. What’s New in Treating Inpatients With Personality Disorders?: Dialectical Behavior Therapy and Old-Fashioned, Good Communication. J Psychosoc Nurs Ment Health Serv. 2016 Jan;54(1):38-45. [PubMed: 26760134]
84.Sansone RA, Sansone LA. Responses of mental health clinicians to patients with borderline personality disorder. Innov Clin Neurosci. 2013 May;10(5-6):39-43. [PMC free article: PMC3719460] [PubMed: 23882440]
85.Parth K, Datz F, Seidman C, Löffler-Stastka H. Transference and countertransference: A review. Bull Menninger Clin. 2017 Spring;81(2):167-211. [PubMed: 28609147]
86.Knaak S, Mantler E, Szeto A. Mental illness-related stigma in healthcare: Barriers to access and care and evidence-based solutions. Healthc Manage Forum. 2017 Mar;30(2):111-116. [PMC free article: PMC5347358] [PubMed: 28929889]
87.Edershile EA, Wright AGC. Fluctuations in grandiose and vulnerable narcissistic states: A momentary perspective. J Pers Soc Psychol. 2021 May;120(5):1386-1414. [PMC free article: PMC8060359] [PubMed: 33090821]
88.Scott KM, de Vries YA, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Bromet EJ, Bunting B, Caldas-de-Almeida JM, Cía A, Florescu S, Gureje O, Hu CY, Karam EG, Karam A, Kawakami N, Kessler RC, Lee S, McGrath J, Oladeji B, Posada-Villa J, Stein DJ, Zarkov Z, de Jonge P., World Mental Health Surveys collaborators. Intermittent explosive disorder subtypes in the general population: association with comorbidity, impairment and suicidality. Epidemiol Psychiatr Sci. 2020 Jun 23;29:e138. [PMC free article: PMC7327434] [PubMed: 32638683]
89.Bateman A, Fonagy P. Comorbid antisocial and borderline personality disorders: mentalization-based treatment. J Clin Psychol. 2008 Feb;64(2):181-94. [PubMed: 18186112]
90.Jemal M, Tessema W, Agenagnew L. Cluster B personality disorders and its associated factors among psychiatric outpatients in Southwest Ethiopia: institutional-based cross-sectional study. BMC Psychiatry. 2022 Jul 26;22(1):500. [PMC free article: PMC9315846] [PubMed: 35883168]
91.Trull TJ, Widiger TA. Dimensional models of personality: the five-factor model and the DSM-5. Dialogues Clin Neurosci. 2013 Jun;15(2):135-46. [PMC free article: PMC3811085] [PubMed: 24174888]
92.Black DW. The Natural History of Antisocial Personality Disorder. Can J Psychiatry. 2015 Jul;60(7):309-14. [PMC free article: PMC4500180] [PubMed: 26175389]
93.Black DW, Monahan P, Baumgard CH, Bell SE. Predictors of long-term outcome in 45 men with antisocial personality disorder. Ann Clin Psychiatry. 1997 Dec;9(4):211-7. [PubMed: 9511944]
94.Burt SA, Donnellan MB, Humbad MN, Hicks BM, McGue M, Iacono WG. Does marriage inhibit antisocial behavior?: An examination of selection vs causation via a longitudinal twin design. Arch Gen Psychiatry. 2010 Dec;67(12):1309-15. [PMC free article: PMC3057675] [PubMed: 21135331]
95.Boot K, Wiebenga JXM, Eikelenboom M, van Oppen P, Thomaes K, van Marle HJF, Heering HD. Associations between personality traits and suicidal ideation and suicide attempts in patients with personality disorders. Compr Psychiatry. 2022 Jan;112:152284. [PubMed: 34763292]
96.De Wit-De Visser B, Rijckmans M, Vermunt JK, van Dam A. Pathways to antisocial behavior: a framework to improve diagnostics and tailor therapeutic interventions. Front Psychol. 2023;14:993090. [PMC free article: PMC9947159] [PubMed: 36844347]
97.Cramer V, Torgersen S, Kringlen E. Personality disorders and quality of life. A population study. Compr Psychiatry. 2006 May-Jun;47(3):178-84. [PubMed: 16635645]
98.James J. Dealing with drug-seeking behaviour. Aust Prescr. 2016 Jun;39(3):96-100. [PMC free article: PMC4919169] [PubMed: 27346918]
99.Collins TN, Avondoglio JB, Terry LM. Correctional psychopharmacology: pitfalls, challenges, and victories of prescribing in a correctional setting. Int Rev Psychiatry. 2017 Feb;29(1):34-44. [PubMed: 27670976]
100.Apeldoorn S, Chavez R, Haschemi F, Elsherif K, Weinstein D, Torrico T. Worsening psychosis associated with administrations of buspirone and concerns for intranasal administration: A case report. Front Psychiatry. 2023;14:1129489. [PMC free article: PMC9981973] [PubMed: 36873224]
101.Mezher AW, McKnight CA, Caplan JP. Buspirone Abuse: No Safe Haven. Psychosomatics. 2019 Sep-Oct;60(5):534-535. [PubMed: 30685117]
102.Stassinos GL, Klein-Schwartz W. Bupropion “Abuse” Reported to US Poison Centers. J Addict Med. 2016 Sep-Oct;10(5):357-62. [PubMed: 27504927]
103.Stall N, Godwin J, Juurlink D. Bupropion abuse and overdose. CMAJ. 2014 Sep 16;186(13):1015. [PMC free article: PMC4162783] [PubMed: 24778361]
104.Jahnsen JA, Widnes SF, Schjøtt J. Quetiapine, Misuse and Dependency: A Case-Series of Questions to a Norwegian Network of Drug Information Centers. Drug Healthc Patient Saf. 2021;13:151-157. [PMC free article: PMC8312250] [PubMed: 34321931]
105.Sansone RA, Sansone LA. Is seroquel developing an illicit reputation for misuse/abuse? Psychiatry (Edgmont). 2010 Jan;7(1):13-6. [PMC free article: PMC2848462] [PubMed: 20386631]